Results 201 to 210 of about 233,575 (303)

Physiological implications of phase separation in vesicle organization and trafficking. [PDF]

BMC Biol
Liu C, Cheng J, Wu X.
europepmc   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Endocytosis Mediated by <i>Candida albicans END3</i> Is Required for Its In Vivo Virulence as an Opportunistic Fungal Pathogen. [PDF]

Microorganisms
Yu M, Gilmore C, Dos Santos E, Eszterhas S, Lee SA.   +4 more
europepmc   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

Ligand-induced ubiquitination regulates endocytosis and homeostasis of the ERECTA receptor kinase for stomatal development. [PDF]

New Phytol
Chen L, Vu MH, Bai P, Cochran AM, Ying CF, Torii KU.   +5 more
europepmc   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Disruption of Synaptic Vesicle Trafficking in Alzheimer's and Parkinson's Disease: Mechanisms and Therapeutic Implication. [PDF]

Int J Mol Sci
Zhu Y, Zhao L, Li Y, Tian M, Liao Y, Huang J, Guo P, Xie Y.   +7 more
europepmc   +1 more source

Silver Nanoparticles (AgNPs) Uptake by Caveolae-Dependent Endocytosis is Responsible for Their Selective Effect Towards Castration Resistant Prostate Cancer

Mariana Morais,1,2 Francisca Dias,1 Patrícia Figueiredo,3 Inês Tavares,1,2 Carla Escudeiro,4,5 Manuel R Teixeira,2,4,5 Alexandra Teixeira,6 Johnny Lisboa,6 Kirsi S Mikkonen,3,7 Ana L Teixeira,1 Rui Medeiros1,2,8– 10 1Molecular Oncology and Viral ...
Tavares I, Escudeiro C, Teixeira AL, Medeiros R, Teixeira A, Dias F, Lisboa J, Morais M, Teixeira MR, Figueiredo P, Mikkonen KS   +10 more
core  

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Super-Resolution Structured Illumination Microscopy to Study Endocytosis and Cellular Nanoparticle Uptake. [PDF]

ACS Nano
Wu Y, Grodzinski P.
europepmc   +1 more source