Results 141 to 150 of about 40,712 (254)

Mutations in the bone morphogenetic protein signaling pathway sensitize zebrafish and humans to ethanol-induced jaw malformations

Disease Models & Mechanisms
John R. Klem, Tae-Hwi Schwantes-An, Marco Abreu, Michael Suttie, Raèden Gray, Hieu D. L. Vo, Grace Conley, Tatiana M. Foroud, Leah Wetherill, Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), C. Ben Lovely   +10 more
doaj   +1 more source

Endoderm Organogenesis

This is the analysis script for our study "Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution," published in Cell, 2025. (https://www.cell.com/cell/abstract/S0092-8674(24)01425-9) Read Readme.R for detailed information on the analysis script and its usage.
openaire   +2 more sources

High‐Grade Immature Teratoma in a 20‐Month‐Old Girl: A Rare Case With Cross‐Midline Presentation and Ovarian Torsion

Reproductive, Female and Child Health, Volume 5, Issue 2, June 2026.
ABSTRACT Background Immature ovarian teratomas are rare malignant germ cell tumours, particularly in children under 2 years old. Ovarian torsion may further obscure diagnosis by altering adnexal anatomy and radiological interpretation. Case Presentation A 20‐month‐old girl presented with persistent vomiting, abdominal distension, and poor oral intake ...
Jia Chyi Tay, Woon Teen Sia, Adrena Abd Wahid, Mohd Fauzi Sharudin   +3 more
wiley   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, Volume 293, Issue 12, Page 3502-3527, June 2026.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Dual Knockout Models of the Spatially and Functionally Conserved rgra and rgrb Zebrafish Genes Reveal the Requirement of RGR for the Integrity of Cone‐Mediated Photopic Vision, the Photopic Visual Cycle and Bruch's Membrane Morphology

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This study investigates the role of the vision gene RGR using novel dual knockout zebrafish models. The loss of rgra and rgrb results in zebrafish larvae having reduced visual function and altered retinoid profiles under light but not dark conditions. The OKR phenotype is enhanced under higher light intensities.
Grace Ruddin, Tess McCann, Joanna J. Kaylor, Michelle M. Fox, John D. Fehilly, Rebecca Ward, Adam Faulkner, Ailís L. Moran, Kieran Wynne, Roxana A. Radu, Michael G. Monaghan, Stephen D. Thorpe, Gabriel H. Travis, Breandán N. Kennedy   +13 more
wiley   +1 more source

The vertebrate yolk sac: evolutionary origins and current advances in in vitro models. [PDF]

Development
Blagrove JR, Orsi AER, Cindrova-Davies T, Niakan KK.   +3 more
europepmc   +1 more source

NSD1 governs H3K36me2-mediated DNA methylation and drives endo-mesodermal differentiation of human iPSCs. [PDF]

Clin Epigenetics
Hansknecht A, Mankarious M, Baranda MV, Torlak ED, Wagner W, Zeevaert K, Puri D.   +6 more
europepmc   +1 more source

Maternal obesity remodels nutrient transport transcriptional programs in early mouse embryonic and extraembryonic cell lineages. [PDF]

Mol Metab
Caballero A, Chi L, Delgado-Olguín P.
europepmc   +1 more source

Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved <i>cis</i>-regulatory modules acting during vertebrate organogenesis. [PDF]

Genome Res
Riley DM, Elsayed R, Walsh MD, Johal S, Lin Y, Walton H, Bretschneider T, Ott S, Nelson AC.   +8 more
europepmc   +1 more source

Harnessing the murine inner cell mass mechanical environment enhances derivation of in vitro nascent primitive endoderm precursor cells. [PDF]

Development
Corujo-Simon E, Salomaa SI, Bates LE, Yanagida A, Mansfield W, Becher H, Nichols J, Chalut KJ.   +7 more
europepmc   +1 more source