Results 51 to 60 of about 36,840 (231)
Definition and variation of human endogenous retrovirus H
Virology, 2004 We defined the abundant human endogenous retrovirus group HERV-H based on pol similarity. Among 3661 pol-containing elements, 1124 integrations were similar to HERV-H RGH2 pol using translated pol sequences. A clustering procedure lessened these to 234 representatives, amenable to detailed study.
Jonas Blomberg +2 more
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Inhibition of budding/release of porcine endogenous retrovirus [PDF]
Microbiology and Immunology, 2014 AbstractPERV is integrated into the genome of all pigs. PERV‐A and PERV‐B are polytropic and can productively infect human cell lines, whereas PERV‐C is ecotropic. Recombinant PERV‐A/C can infect human cells and exhibits high titer replication. Therefore, use of pigs for human xenotransplantation raises concerns about the risks of transfer of this ...
Takayuki Miyazawa +6 more
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Acquisition and Exaptation of Endogenous Retroviruses in Mammalian Placenta
Biomolecules, 2023 Endogenous retroviruses (ERVs) are retrovirus-like sequences that were previously integrated into the host genome. Although most ERVs are inactivated by mutations, deletions, or epigenetic regulation, some remain transcriptionally active and impact host ...
Sayumi Shimode
doaj +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors
eLife, 2017 Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction.
Daniel Blanco-Melo +2 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen +18 more
wiley +1 more source
Advanced Science, EarlyView.Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li +13 more
wiley +1 more source
Evidence and Consequence of Porcine Endogenous Retrovirus Recombination [PDF]
Journal of Virology, 2004 ABSTRACT The genetic nature and biological effects of recombination between porcine endogenous retroviruses (PERV) were studied. An infectious molecular clone was generated from a high-titer, human-tropic PERV isolate, PERV-A 14/220 (B. A. Oldmixon, et al. J. Virol. 76: 3045-3048, 2002; T. A.
Dimitrios Stefanidis +5 more
openaire +3 more sources
PLoS ONE, 2008 Two sequences of major histocompatibility complex (MHC) regions in the domestic cat, 2.976 and 0.362 Mbps, which were separated by an ancient chromosome break (55-80 MYA) and followed by a chromosomal inversion were annotated in detail.
Naoya Yuhki +4 more
doaj +1 more source
ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source