Results 41 to 50 of about 71,944 (228)

Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases [PDF]

BioMed Research International, 2017
At least 8% of the human genome is composed of endogenous retrovirus (ERV) sequences. ERVs play a role in placental morphogenesis and can sometimes protect the host against exogenous viruses. On the other hand, ERV reactivation has been found to be associated with different diseases, for example, multiple sclerosis (MS), schizophrenia, type 1 diabetes ...
Christine Brütting, Alexander Emmer, Malte E. Kornhuber, Martin S. Staege   +3 more
openaire   +2 more sources

Investigation of Endogenous Retrovirus Sequences in the Neighborhood of Genes Up-regulated in a Neuroblastoma Model after Treatment with Hypoxia-Mimetic Cobalt Chloride

Frontiers in Microbiology, 2018
Human endogenous retroviruses (ERVs) have been found to be associated with different diseases, e.g., multiple sclerosis (MS). Most human ERVs integrated in our genome are not competent to replicate and these sequences are presumably silent.
Christine Brütting, Christine Brütting, Harini Narasimhan, Frank Hoffmann, Malte E. Kornhuber, Martin S. Staege, Alexander Emmer   +6 more
doaj   +1 more source

Human Endogenous Retrovirus-like Sequences

, 1989
One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed “provirus”, can then serve as a template for the synthesis of further infectious virus particles ...
Brack-Werner, R., Leib-Mösch, C., Werner, T., Erfle, V.F., Hehlmann, R.   +4 more
openaire   +3 more sources

Genomic Flexibility of Human Endogenous Retrovirus Type K [PDF]

Journal of Virology, 2013
ABSTRACT Human endogenous retrovirus type K (HERV-K) proviruses are scattered throughout the human genome, but as no infectious HERV-K virus has been detected to date, the mechanism by which these viruses replicated and populated the genome remains unresolved.
Dube, Derek, Contreras-Galindo, Rafael, He, Shirley, King, Steven, Gonzalez-Hernandez, Marta, Gitlin, Scott, Kaplan, Mark, Markovitz, David   +7 more
openaire   +3 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Arc – An endogenous neuronal retrovirus?

Seminars in Cell & Developmental Biology, 2018
The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and has been implicated in various neurological disorders. However, little is known about Arc's evolutionary origins. Recent studies suggest that mammalian Arc originated from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to ...
openaire   +3 more sources

Amplification of simian retroviral sequences from human recipients of baboon liver transplants [PDF]

, 1998
Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases ...
Anonymous, ANTHONY G. COMUZZIE, EVELYN M. WHITEHEAD, JONATHAN S. ALLAN, KAREN L. LEIGHTON, M. MICHELLE LELAND, MARIAN G. MICHAELS, ROBERT E. LANFORD, SUZANNE R. BROUSSARD, THOMAS E. STARZL, van der Kuyl AC, WALID HENEINE, WILLIAM M. SWITZER   +12 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

Nature Communications
The development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hypothesized ...
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Carole Zaratiegui, Hin-Man Tai, Gabriele Ciceri, Ina Rothenaigner, Jason Tchieu, Brent R. Stockwell, Lorenz Studer, Daphne S. Cabianca, Michael P. Menden, Michelle Vincendeau, Kamyar Hadian   +13 more
doaj   +1 more source

Evaluation of the Broad-Range PCR-Electrospray Ionization Mass Spectrometry (PCR/ESI-MS) System and Virus Microarrays for Virus Detection

Viruses, 2014
Advanced nucleic acid-based technologies are powerful research tools for novel virus discovery but need to be standardized for broader applications such as virus detection in biological products and clinical samples.
Lanyn P. Taliaferro, Teresa A. Galvin, Hailun Ma, Syed Shaheduzzaman, Dhanya K. Williams, Dustin R. Glasner, Arifa S. Khan   +6 more
doaj   +1 more source