Results 71 to 80 of about 36,840 (231)

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus

Nature Communications, 2017
The gene-battery model posits transposable elements (TEs) may becis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act as ...
Vasavi Sundaram, Mayank N. K. Choudhary, Erica Pehrsson, Xiaoyun Xing, Christopher Fiore, Manishi Pandey, Brett Maricque, Methma Udawatta, Duc Ngo, Yujie Chen, Asia Paguntalan, Tammy Ray, Ava Hughes, Barak A. Cohen, Ting Wang   +14 more
doaj   +1 more source

Investigating the role of SARM1 in central nervous system

Ibrain, EarlyView.
Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1) is a pivotal molecule that has garnered extensive attention in neuroscience. As an intracellular molecule, SARM1 possesses various crucial biological functions in the nervous system.
Junjie Wang, Yuhang Shi, Jinglei Tian, Liming Tang, Fang Cao   +4 more
wiley   +1 more source

Emv2, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice

Retrovirology, 2012
With the proliferation of sequence data, great challenges are posed in the correct annotation of endogenous retroviruses, which together comprise up to ten per cent of the genomes of many organisms.
Young George R, Kassiotis George, Stoye Jonathan P   +2 more
doaj   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Characterization of the human endogenous retrovirus K proteinase

Journal of General Virology, 1996
The proteinase of the human endogenous retrovirus K (HERV-K) shows similarity to retrovirus aspartic proteinases. It is translated from a transcript composed of gag and prt. The proteinase was expressed either as full-length native protein or as truncated protein in Escherichia coli.
Marlies Sauter, Hans-Georg Kräusslich, Barbara Best, Nikolaus Mueller-Lantzsch, Stefanie Schommer   +4 more
openaire   +3 more sources

Genomic Flexibility of Human Endogenous Retrovirus Type K [PDF]

Journal of Virology, 2013
ABSTRACT Human endogenous retrovirus type K (HERV-K) proviruses are scattered throughout the human genome, but as no infectious HERV-K virus has been detected to date, the mechanism by which these viruses replicated and populated the genome remains unresolved.
David M. Markovitz, Rafael Contreras-Galindo, Scott D. Gitlin, Marta J. Gonzalez-Hernandez, Mark H. Kaplan, Steven R. King, Derek Dube, Shirley He   +7 more
openaire   +5 more sources

Loss of histone reader Phf7 leads to immune pathways activation via endogenous retroviruses during spermiogenesis

iScience, 2023
Summary: Genetic studies have elucidated the critical roles of Phf7 in germline development in animals; however, the exact etiology of Phf7 mutations leading to male infertility and the possibility of mechanism-based therapy are still unclear and warrant
Jianxing Cheng, Tongtong Li, Zhongjie Zheng, Xueguang Zhang, Mengyang Cao, Wenhao Tang, Kai Hong, Rui Zheng, Jichun Shao, Xiaomiao Zhao, Hui Jiang, Wenming Xu, Haocheng Lin   +12 more
doaj  

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

Sensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He, Shanying Han, Xinghong Liu, Xiaotong Huang, Wen Yang, Xinghua Tang, Chuan Dong, Jiangang Fan   +7 more
wiley   +1 more source

IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS

Медицинская иммунология, 2014
A comparative in vitro study of blood mononuclear cells from multiple sclerosis patients and healthy donors was performed, in order to evaluate proliferative response to a retroviral antigen, aiming to determine immunomodulatory properties of synthetic ...
A. A. Smagin, I. A. Goldina, K. V. Gaidul, M. S. Lubarsky   +3 more
doaj   +1 more source