Results 81 to 90 of about 71,944 (228)
Virology, 2003 The chronic shortage of human donor organs and tissues for allotransplantation could be relieved if clinical xenotransplantation were to become a viable clinical therapy. Balanced against the benefits of xenotransplantation are the possible consequences of zoonotic infections, and in particular, infection by porcine endogenous retrovirus (PERV).
Suling, Kristen +3 more
openaire +2 more sources
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Retrovirus insertion site analysis of LGL leukemia patient genomes
BMC Medical Genomics, 2019 Background Large granular lymphocyte (LGL) leukemia is an uncommon cancer characterized by sustained clonal proliferation of LGL cells. Antibodies reactive to retroviruses have been documented in the serum of patients with LGL leukemia.
Weiling Li +8 more
doaj +1 more source
The baboon endogenous virus genome. II. Provirus sequence variations in baboon cell DNA [PDF]
, 1980 Restriction analysis of the approximately 100 integrated baboon endogenous virus (BaEV) proviruses in baboon cells and tissues has revealed two major sequence variations, both in the gag gene region of the genome.
Cohen, Maurice +5 more
core +1 more source
Detecting Endogenous Retrovirus-Driven Tissue-Specific Gene Transcription [PDF]
Genome Biology and Evolution, 2015 Transposable elements (TEs) comprise approximately half of the human genome, and several independent lines of investigation have demonstrated their role in rewiring gene expression during development, evolution, and oncogenesis. The identification of their regulatory effects has largely been idiosyncratic, by linking activity with isolated genes. Their
Pavlicev, Mihaela +4 more
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2016 Avian leukosis virus subgroup J (ALV-J) infection can cause tumors and immunosuppression. Endogenous viruses integrate into host genomes and can recombine with exogenous avian leukosis virus (ALV). In this study, we analyzed the interaction of endogenous
Min Feng +7 more
doaj +1 more source
Human Endogenous Retrovirus K (HML-2) in Health and Disease
Frontiers in Microbiology, 2020 Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections in the evolution of primates and account for about 8% of the human genome.
Bei Xue +6 more
doaj +1 more source
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]
, 2019 Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Amaral, Maria Luisa +21 more
core +2 more sources
Human endogenous retrovirus K10 encodes a functional integrase [PDF]
Journal of Virology, 1996 We cloned a human endogenous retrovirus K1O DNA fragment encoding integrase and expressed it as a fusion protein with Escherichia coli maltose-binding protein. Integrase activities were measured in vitro by using a double-stranded oligonucleotide as a substrate mimicking viral long terminal repeats (LTR).
Y, Kitamura +4 more
openaire +2 more sources
Current Status of Kidney Xenotransplantation in Basic Research
Organ Medicine, EarlyView.Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley +1 more source