Results 171 to 180 of about 13,041 (209)

Endoglin mediates the tumor- and metastasis-promoting traits of stromal myofibroblasts in human breast carcinomas. [PDF]

Mol Oncol
Okubo S, Mezawa Y, Wang Z, Acar A, Ito Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Daigo Y, Shirakihara T, Orimo A.   +11 more
europepmc   +1 more source

The Loss of Endoglin Promotes the Invasion of Extravillous Trophoblasts

Endocrinology, 2011
Endoglin is a coreceptor for TGF-β, which is expressed in syncytiotrophoblasts. The soluble form of endoglin (sEng) has been observed to increase in the serum of preeclamptic patients.
Yukio Mano, Tomomi Kotani
exaly   +2 more sources

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The role of endoglin in atherosclerosis

Atherosclerosis, 2012
Endoglin (CD 105, TGF-β receptor III) is a homodimeric transmembrane glycoprotein that plays a regulatory role in TGF-β signaling. Its functional role in the context of atherosclerosis has yet to be defined and should be stated here. Therefore, we focused on the role of endoglin in atherosclerosis in both humans and experimental animals.
Petr, Nachtigal, Lenka, Zemankova Vecerova, Jana, Rathouska, Zbynek, Strasky   +3 more
openaire   +2 more sources

Peptides do not prevent cleavage of endoglin to produce soluble endoglin

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2014
MMP14 cleaves membrane bound endoglin to produce soluble endoglin (sEng), an anti-angiogenic factor that causes endothelial dysfunction in preeclampsia. A recent publication proposed peptides with an amino acid sequence straddling the MMP14 cleavage site on endoglin decreases sEng release.
Roxanne, Hastie, Stephen, Tong, Ping, Cannon, Fiona, Brownfoot, Natalie J, Hannan, Tu'uhevaha, Kaitu'u-Lino   +5 more
openaire   +2 more sources

Endoglin in angiogenesis and vascular diseases

Angiogenesis, 2008
Endoglin is a transmembrane auxillary receptor for transforming growth factor-beta (TGF-beta) that is predominantly expressed on proliferating endothelial cells. Endoglin deficient mice die during midgestation due to cardiovascular defects. Mutations in endoglin and activin receptor-like kinase 1 (ALK1), an endothelial specific TGF-beta type I receptor,
Peter, ten Dijke, Marie-José, Goumans, Evangelia, Pardali   +2 more
openaire   +2 more sources

Endoglin as a marker in cervical paragangliomas

Head & Neck, 2009
AbstractBackgroundEndoglin is expressed on endothelium and is implicated in the control of angiogenesis. This study compares the expression of endoglin with vascular endothelial growth factor (VEGF), commonly used as a marker for neoangiogenesis in cervical paragangliomas (CPG).MethodsThe CPG were surgically obtained from 5 patients and compared with ...
Nélida, Eleno, Annette, Düwel, Angel, Muñoz, José, Paz-Bouza, Jose-Miguel, López-Novoa, Francisco, Lozano   +5 more
openaire   +2 more sources

Endoglin for Targeted Cancer Treatment

Current Oncology Reports, 2014
Endoglin is a homodimeric cell membrane glycoprotein receptor for transforming growth factor β and bone morphogenetic proteins. Endoglin is essential for angiogenesis, being densely expressed on proliferating endothelial cells and upregulated during hypoxia. Its expression is implicated in development of resistance to vascular endothelial growth factor
Lee S, Rosen, Michael S, Gordon, Francisco, Robert, Daniela E, Matei   +3 more
openaire   +2 more sources

The role of endoglin in kidney fibrosis

Expert Reviews in Molecular Medicine, 2014
Tubulointerstitial fibrosis and glomerulosclerosis, are a major feature of end stage chronic kidney disease (CKD), characterised by an excessive accumulation of extracellular matrix (ECM) proteins. Transforming growth factor beta-1 (TGF-β1) is a cytokine with an important role in many steps of renal fibrosis such as myofibroblast activation and ...
Jose M, Muñoz-Felix, Barbara, Oujo, Jose M, Lopez-Novoa   +2 more
openaire   +2 more sources