Results 151 to 160 of about 10,232 (247)
British Journal of Haematology, Volume 207, Issue 5, Page 2187-2191, November 2025.
Akihisa Hino +11 more
wiley +1 more source
Molecular Therapy: Nucleic AcidsEndolysins are bacteriophage-encoded hydrolases that show high antibacterial activity and a narrow substrate spectrum. We hypothesize that an mRNA-based approach to endolysin therapy can overcome some challenges of conventional endolysin therapy, namely ...
Moritz K. Jansson +7 more
doaj +1 more source
MmpL3 is the flippase for mycolic acids in mycobacteria [PDF]
, 2017 The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to external insults, including many antibiotics.
Chng, Shu-Sin +3 more
core +1 more source
Characterization of Clostridium perfringens Phage Endolysin PlyDolk21
AntibioticsBackground: Clostridium perfringens is a significant cause of food poisoning. Broad-spectrum antibiotics, commonly used to control C. perfringens, are becoming less effective due to the rise of antibiotic-resistant strains, necessitating alternative control strategies. Methods: A C.
Suyoung Seo, Bokyung Son, Minsuk Kong
openaire +2 more sources
Distribution and composition of the lysis cassette of Lactococcus lactis phages and functional analysis of bacteriophage ul36 holin [PDF]
, 2017 The bacteriophage lysis cassette, which comprises a lysin and a holin gene, was analyzed in 18 Lactococcus lactis phages. A muramidase motif was found in the lysins of c2-like phages, while an amidase motif was observed in the lysins of 936-like phages ...
Labrie, Steve +3 more
core
Frontiers in MicrobiologyThe rise of antimicrobial resistance in ESKAPEE pathogens poses significant clinical challenges, especially in polymicrobial infections. Bacteriophage-derived endolysins offer promise in combating this crisis, but face practical hurdles.
Wei Chen +11 more
semanticscholar +1 more source
Characterization of PlyPl23, an endolysin from a Paenibacillus larvae bacteriophage [PDF]
, 2014 EMBO Conference on Viruses of Microbes III: Structure and Function - from Molecules to Communities (Programme and Abstract Book)Bees pollination presents a great impact in a wide range of terrestrial ecosystems.
Azeredo, Joana +4 more
core
Fermentation Practices Select for Thermostable Endolysins in Phages
Molecular Biology and EvolutionAbstract Endolysins are produced by (bacterio)phages and play a crucial role in degrading the bacterial cell wall and the subsequent release of new phage progeny. These lytic enzymes exhibit a remarkable diversity, often occurring in a multimodular form that combines different catalytic and cell wall-binding domains, even in phages ...
Frank Oechslin +5 more
openaire +2 more sources
Phage endolysins: Structure, function and applications
Science and Technology Development Journal-Natural SciencesAntibiotic resistance has emerged and persisted as one of the major threats to public health and the sustainable development of healthcare systems worldwide in recent years. The primary reason why antibiotic resistance is regarded as a global medical crisis lies in the development of new antibiotics is not keeping pace with the emergence of antibiotic ...
Yen-Vy Le-Nguyen, Hieu Tran-Van
openaire +1 more source
Gram-negative endolysins: overcoming the outer membrane obstacle
Current Opinion in MicrobiologyOur ability to control the growth of Gram-negative bacterial pathogens is challenged by rising antimicrobial resistance and requires new approaches. Endolysins are phage-derived enzymes that degrade peptidoglycan and therefore offer potential as antimicrobial agents.
Hazel M, Sisson +4 more
openaire +2 more sources