Results 221 to 230 of about 10,232 (247)

Combined antimicrobial effect of phage-derived endolysin and depolymerase against biofilm-forming Salmonella Typhimurium

Biofouling (Print), 2023
This study was designed to evaluate the antimicrobial activity of phage-derived endolysin (LysPB32) and depolymerase (DpolP22) against planktonic and biofilm cells of Salmonella Typhimurium (STKCCM).
Junhwan Kim, Jun Wang, Juhee Ahn
semanticscholar   +1 more source

Molecular Machinery of the Triad Holin, Endolysin, and Spanin: Key Players Orchestrating Bacteriophage-Induced Cell Lysis and their Therapeutic Applications.

Protein Peptide Letters
Phage therapy has attracted attention as a possible alternative treatment for multi-drug resistance (MDR) infections in recent years. The lytic bacteriophages encode proteins for bacterial host envelope rupture.
Safia Samir
semanticscholar   +1 more source

Bacteriophage-derived endolysins to target gram-negative bacteria

International Journal of Pharmaceutics, 2020
Bacteriophage-encoded endolysins (lysins) have emerged as a novel class of antibacterial agents to combat the surging antibiotic resistance. Lysins have specific structures and mechanisms to exert antibacterial effect against both Gram-positive (G+ve) and Gram-negative (G-ve) bacteria. However, its use against G-ve bacteria is limited because the outer
Wing Ching Bianca, Lai, Xi, Chen, Marco Kai Yuen, Ho, Jiang, Xia, Sharon Shui Yee, Leung   +4 more
openaire   +2 more sources

C‐terminal anchor endolysins—proposing a third class of tailed bacteriophage endolysins

FEBS Letters
Endolysins—enzymes produced by tailed bacteriophages to degrade bacterial cell walls—have traditionally been classified as canonical or signal‐anchor‐release (SAR) endolysins. However, analysis of expanding viral (meta)genomic data has revealed a third class, which we designate as C‐terminal anchor (CTA) endolysins.
Elina Cernooka, Nikita Zrelovs, Andris Kazaks   +2 more
openaire   +2 more sources

Endolysins: Redefining Antibacterial Therapy

Future Microbiology, 2015
Bjorn Lars Herpers speaks to Natasha Leeson, Commissioning Editor: Bjorn Lars Herpers was born on 16 February 1974 in Schaesberg. In 1992 he graduated summa cum laude at Gymnasium Rolduc in Kerkrade (The Netherlands) and started to study medical biology at the University of Utrecht. After 3 years, he started to study medicine as well.
openaire   +1 more source

Endopeptidase Activity of Phage λ-Endolysin

Nature New Biology, 1971
JACOB and Fuerst1,2 demonstrated the presence of a bacteriolytic enzyme (λ-endolysin) in the induced cultures of lysogenic Escherichia coli K12 (λ). The enzyme was later identified as the product of gene R; of phage λ3 which is involved in bacterial lysis at the end of a latent period. The enzyme is apt to form spheroplast-like structures in E.
openaire   +2 more sources

Combined effect of SAR-endolysin LysKpV475 with polymyxin B and Salmonella bacteriophage phSE-5

Microbiology
: Endolysins are bacteriophage (or phage)-encoded enzymes that catalyse the peptidoglycan breakdown in the bacterial cell wall. The exogenous action of recombinant phage endolysins against Gram-positive organisms has been extensively studied.
M. Gontijo, Mateus Pereira Teles, Hugo Martins Correia, Genesy Pérez Jorge, Isabella Carolina Rodrigues Santos Goes, Anthony Jhoao Fasabi Flores, Márcia Braz, Lucas de Moraes Ceseti, Priscila Zonzini Ramos, Ivan Rosa E Silva, P. M. Pereira Vidigal, Jörg Kobarg, Rafael Miguez Couñago, C. Alvarez-Martinez, C. Pereira, CarmenS.R. Freire, Adelaide Almeida, Marcelo Brocchi   +17 more
semanticscholar   +1 more source

The effectiveness of endolysin ENDO-1252 from Salmonella bacteriophage-1252 against nontyphoidal Salmonella enterica.

FEMS Microbiology Letters
Salmonella enterica (S. enterica) is the most common food and waterborne pathogen worldwide. The growing trend of antibiotic-resistant S. enterica poses severe healthcare threats.
Chuan-Wei Tung, Dita Julianingsih, Christa Canagarajah, George Sellers, Aaron Scriba, Zabdiel Alvarado-Martínez, Zajeba Tabashsum, Debabrata Biswas   +7 more
semanticscholar   +1 more source

Construing the function of N‐terminal domain of D29 mycobacteriophage LysA endolysin in phage lytic efficiency and proliferation

Molecular Microbiology
Endolysins produced by bacteriophages hydrolyze host cell wall peptidoglycan to release newly assembled virions. D29 mycobacteriophage specifically infects mycobacteria including the pathogenic Mycobacterium tuberculosis.
Rutuja Gangakhedkar, V. Jain
semanticscholar   +1 more source

Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa

mSystems
Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading to the activation of the gasdermin D (GSDMD) and secretion of pore-forming domain GSDMDNterm, facilitating the
D. Kuc-Ciepluch, K. Ciepluch, Daria Augustyniak, Grzegorz Guła, B. Maciejewska, Artur Kowalik, Ewelina Jop, Z. Drulis-Kawa, M. Arabski   +8 more
semanticscholar   +1 more source