Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis [PDF]
, 2020 Atypical polypoid adenomyoma (APA) is a rare uterine lesion constituted by atypical endometrioid glands, squamous morules, and myofibromatous stroma. We aimed to assess the immunophenotype of the 3 components of APA, with regard to its pathogenesis and ...
Aggarwal +46 more
core +1 more source
On a fundamental problem in the analysis of cancer registry data [PDF]
arXiv, 2023 In epidemiology research with cancer registry data, it is often of primary interest to make inference on cancer death, not overall survival. Since cause of death is not easy to collect or is not necessarily reliable in cancer registries, some special methodologies have been introduced and widely used by using the concepts of the relative survival ratio
arxiv
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action [PDF]
, 2010 Endometrial cancer is the most common gynecological cancer. Estrogen-dependent endometrioid carcinoma is the most common type of endometrial cancer, and alterations in the expression of PTEN and K-ras have been associated with this disease.
Broaddus, Russell R. +7 more
core +3 more sources
Frontiers in MedicineObjectiveUnderstanding the mechanisms underlying endometrial cancer progression is crucial for the development of effective targeted therapies. In this study, we investigated the role of MTFR2 in endometrial cancer cell.MethodsThe expression of MTFR2 in ...
Zhijun Niu +7 more
doaj +1 more source
Patterns of care and outcomes for endometrial and ovarian cancers in botswana 2015–2021
Gynecologic Oncology Reports, 2023 Purpose: Endometrial and ovarian cancers are leading causes of cancer death among women. However, there is little data on these patients from low- and middle-income countries including Botswana, a country in sub-Saharan Africa. This study reports data on
Christian Lumley +13 more
doaj
Bayesian Nonparametric Cost-Effectiveness Analyses: Causal Estimation and Adaptive Subgroup Discovery [PDF]
arXiv, 2020 Cost-effectiveness analyses (CEAs) are at the center of health economic decision making. While these analyses help policy analysts and economists determine coverage, inform policy, and guide resource allocation, they are statistically challenging for several reasons. Cost and effectiveness are correlated and follow complex joint distributions which are
arxiv
What is currently known about endometrial cancer in Lynch syndrome? - review [PDF]
, 2019 Introduction: About 5% of endometrial cancer cases can be genetic and inherited. Lynch syndrome, also called hereditary non-polyposis colorectal cancer (HNPCC), is an autosomal dominant syndrome.
Krawczyk, Dominika +4 more
core +2 more sources
, 2016 National audienceObjective - To assess the use of French Cancer Institute recommendations for the diagnosis and treatment of endometrial cancer. Methods - Retrospective observational study involving 137 patients with endometrial cancer between 2011 and ...
Body, N. +10 more
core +2 more sources
Genome-Wide Association Studies of Endometrial Cancer: Latest Developments and Future Directions. [PDF]
, 2019 Endometrial cancer, the most commonly diagnosed cancer of the female reproductive tract in developed countries, has a heritable component. To date, 16 genetic risk regions have been robustly discovered by genome-wide association studies (GWAS) of ...
Glubb, Dylan M +4 more
core +1 more source
A Weighted Exact Test for Mutually Exclusive Mutations in Cancer [PDF]
arXiv, 2016 The somatic mutations in the pathways that drive cancer development tend to be mutually exclusive across tumors, providing a signal for distinguishing driver mutations from a larger number of random passenger mutations. This mutual exclusivity signal can be confounded by high and highly variable mutation rates across a cohort of samples.
arxiv