Results 71 to 80 of about 212,484 (305)

Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines [PDF]

, 2019
Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme constituted by two subunits, α1 and β1. Previously we have shown that 17β-estradiol (E2) exerts opposite effects on these subunits by increasing α1 and decreasing both β1 expression and enzymatic ...
Bollani, Sabrina Natalia, Cabilla, Jimena Paula, Cordeiro, Georgina, Duvilanski, Beatriz Haydee, Pino, María Teresa Luján, Ricci, Analía Gabriela, Ronchetti, Sonia Alejandra   +6 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Prognostic factors for rural endometrial cancer patients in a population-based cohort

BMC Public Health, 2019
Background Endometrial cancer is the second most common cancer among female cancer survivors in the US and is increasing in incidence. Rural endometrial cancer patients experience lower survival rates but the reasons for the lower survival are not known.
Brenna E. Blackburn, Sean Soisson, Kerry Rowe, John Snyder, Alison Fraser, Vikrant Deshmukh, Michael Newman, Ken Smith, Kimberly Herget, Anne C. Kirchhoff, Deanna Kepka, Theresa L. Werner, David Gaffney, Kathi Mooney, Mia Hashibe   +14 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Evaluation of Preoperative Hematological Parameters in Patients with Endometrial Adenocarcinoma

Bagcilar Medical Bulletin, 2023
Objective:The aim of the study was to compare mean platelet volume (MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), eosinophil-lymphocyte ratio (ELR), platelet/lymphocyte ratio (PLR) between ...
Serkan Kumbasar, Dilruba Karaca, Fatma Ketenci Gencer, Özlem Khatip, Hatice Yaşat Nacar, Nazime Binnur Cömert, Esra Nazlı Döktür   +6 more
doaj   +1 more source

Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity [PDF]

, 2013
While Chlamydia trachomatis infections are frequently asymptomatic, mechanisms that regulate host response to this intracellular Gram-negative bacterium remain undefined.
AL Graham, AN Barclay, B Pulendran, BJ Wilson, C Cobaleda, C Soo, C Van Themsche, CR Cohen, Dean B. Matthews, FO Martinez, G Schaefer, G Tanaka, J Turner, JE Allen, JE Allen, JF Peipert, Jörn Coers, M Busslinger, M Molano, M Stein, M Wang, MJ Jardim, RC Brunham, RD Vicetti Miguel, RD Vicetti Miguel, RD Vicetti Miguel, RD Vicetti Miguel, RJ Snelgrove, RM Anthony, RM Hoek, Rodolfo D. Vicetti Miguel, S Fichtner-Feigl, S Fichtner-Feigl, S Fujisaka, Seth D. Reighard, Stephen A. K. Harvey, T Darville, Thomas L. Cherpes, V Hebbar, VH Hu, W Conca, William A. LaFramboise, WM Geisler   +42 more
core   +3 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Identify effect of SERPINA3 up-regulated expression in endometrial cancer

Zhongguo aizheng zazhi, 2014
Background and purpose: SERPINA3 is a protease inhibitor, belonging to the serpin super family. It has been reported that SERPINA3 expression up-regulated in various tumor cells.
杨广东, 任渊, 张蓉
doaj  

Pancancer analysis of DNA methylation-driven genes using MethylMix. [PDF]

, 2015
Aberrant DNA methylation is an important mechanism that contributes to oncogenesis. Yet, few algorithms exist that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer.
Gevaert, Olivier, Plevritis, Sylvia K, Tibshirani, Robert   +2 more
core   +2 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source