Results 51 to 60 of about 3,374,023 (302)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Predicting positive and negative impacts of cancer among long-term endometrial cancer survivors

, 2013
Objective Although the survival outcomes among women diagnosed with endometrial cancer are very favorable, little is known about the long-term impact of their cancer experience.
Obermair, Andreas, Webb, Penelope M., Lee, Christina, Nagle, Christina M., Rowlands, Ingrid J., Janda, Monika, Australian National Endometrial Cancer Study Group, Lee , Christina   +7 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Correlation of Hypothyroidism and Endometrial Carcinoma

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the relationship between hypothyroidism and endometrial carcinoma, and to explore the relationship of the differentiation degree of endometrial carcinoma, the expression of estrogen receptor (ER) and progesterone receptor (PR) in
LIAO Yuping, YANG Bing
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Relations of platelet indices with endometrial hyperplasia and endometrial cancer

, 2015
Background: Platelets are blood elements thought to play a role in the immune system and therefore tumor development and metastasis. Platelet activation parameters such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit ...
Karateke, Atilla, Kaplanoglu, Mustafa, Baloglu, Ali   +2 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Detecting endometrial cancer by blood spectroscopy: A diagnostic cross-sectional study [PDF]

, 2020
Endometrial cancer is the sixth most common cancer in women with a rising incidence worldwide. Current approaches for the diagnosis and screening of endometrial cancer are invasive, expensive and of moderate diagnostic accuracy, limiting their clinical ...
Crosbie, Emma J, Ryan, Neil AJ, McVey, Rhona J, Derbyshire, Abigail E., Rhona J. McVey, Lima, Kassio M. G., Morais, Camilo LM, Maria Kyrgiou, Pow, Cecilia, Lima, Kassio MG, Stringfellow, Helen, Medeiros-De-morais, Camilo De lelis, Ryan, Neil A.J., Maria Paraskevaidi, Camilo L. M. Morais, Stringfellow, Helen F, Ryan, Neil, Stringfellow, Helen F., Pierre L. Martin-Hirsch, Derbyshire, Abigail E, Kyrgiou, Maria, Martin-Hirsch, Pierre L., MacKintosh, Michelle L., Abigail E. Derbyshire, Sivalingam, Vanitha, Emma J. Crosbie, Morais, Camilo L M, Katherine M. Ashton, Helen F. Stringfellow, Crosbie, Emma J., Ashton, Katherine, Lima, Kássio M.G., Francis L. Martin, Sarah J. Kitson, Neil A. J. Ryan, Derbyshire, Abigail, Martin, Francis, Paraskevaidi, Maria, Kitson, Sarah J., Ryan, Neil A J, Martin-Hirsch, Pierre L, Olivia Raglan, Raglan, Olivia, Lima, Kássio M G, Kássio M. G. Lima, Martin, Francis L, Kitson, Sarah; id_orcid, Helena O’Flynn, Michelle L. MacKintosh, O’Flynn, Helena, Crosbie, Emma; id_orcid, Kitson, Sarah J, MacKintosh, Michelle L, Cecilia Pow, Mackintosh, Michelle, Sivalingam, Vanitha N., McVey, Rhona J., Sivalingam, Vanitha N, Morais, Camilo L.M., O'Flynn, Helena, Ashton, Katherine M., Ashton, Katherine M, Vanitha N. Sivalingam, O'Flynn, Helena   +63 more
core   +1 more source

Genetics of Endometrial Cancers [PDF]

Obstetrics and Gynecology International, 2010
Endometrial cancers exhibit a different mechanism of tumorigenesis and progression depending on histopathological and clinical types. The most frequently altered gene in estrogen‐dependent endometrioid endometrial carcinoma tumors is PTEN. Microsatellite instability is another important genetic event in this type of tumor. In contrast, p53 mutations or
Tsuyoshi Okuda, Akihiko Sekizawa, Yuditiya Purwosunu, Masaaki Nagatsuka, Miki Morioka, Masaki Hayashi, Takashi Okai   +6 more
openaire   +3 more sources