Results 191 to 200 of about 127,260 (361)

Landscape Analysis of CLDN18 Expression and Isoform Distribution in Solid Tumors: Insights From MONSTAR‐SCREEN‐2 Study

Cancer Science, EarlyView.
ABSTRACT Claudin 18.2 (CLDN18.2), a tight junction protein isoform, is an emerging therapeutic target in oncology. CLDN18 is well‐characterized in gastric cancer, but its pan‐cancer expression profiles and isoform distributions are poorly documented.
Tadayoshi Hashimoto, Naoko Iida, Yoshiaki Nakamura, Norio Nonomura, Chigusa Morizane, Hiroji Iwata, Susumu Okano, Wataru Yamagami, Naoya Yamazaki, Shigenori Kadowaki, Makoto Ueno, Shogen Boku, Eiji Oki, Yoshito Komatsu, Satoshi Yuki, Akitaka Makiyama, Takatsugu Ogata, Naoki Takahashi, Naohiro Okano, Tomohiro Nishina, Naoya Sakamoto, Takeshi Kuwata, Riu Yamashita, Taro Shibuki, Mitsuho Imai, Takao Fujisawa, Hideaki Bando, Kohei Shitara, Takayuki Yoshino   +28 more
wiley   +1 more source

A Case of Asymptomatic Postmenopausal Hematometra Mimicking Endometrial Carcinoma

Gynecology Obstetrics & Reproductive Medicine, 2007
Hematometra in a postmenopausal woman is a rare condition and the possible association of endometrial and cervical carcinoma should be excluded for such cases.
Süleyman Güven, Turan Ilıca, Alpay Yılmaz, İbrahim Alanbay   +3 more
doaj  

Ligand‐Based CAR‐T Cells Targeting EGFR Exhibit Favorable Antitumor Effects Against Gynecologic Malignancies

Cancer Science, EarlyView.
Wide variety of gynecologic malignancies express EGFR at high rates. Memory‐rich EGFR CAR‐T cells can be made by piggyBac‐mediated gene transfer with immature dendritic cells and EGFR protein. Ligand‐based EGFR CAR‐T cells have robust antitumor effects against gynecologic malignancies in vivo and in vitro.
Manaka Shinagawa, Koichi Hirabayashi, Marina Fujioka, Kyosuke Kamijo, Natsuki Uchiyama, Yusuke Yokokawa, Yasuhiro Tanaka, Motoki Ono, Thanyavi Chinsuwan, Ryoichi Asaka, Aiko Hasegawa, Miyuki Tanaka, Takashi Murakami, Shigeki Yagyu, Tsutomu Miyamoto, Tanri Shiozawa, Yozo Nakazawa   +16 more
wiley   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, EarlyView.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

CD105 (Endoglin) Expression as a Prognostic Marker in Aggressive Papillary Thyroid Carcinoma

Clinical Endocrinology, EarlyView.
ABSTRACT Background Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with a generally favourable prognosis. However, a subset of PTC cases exhibit aggressive behaviour, including lymph node and distant organ metastases. Identifying biomarkers that can differentiate between benign and malignant lesions, as well as predict
İlker Çordan, Tuğba Günler
wiley   +1 more source

Involvement of mutations in theDPC4 promoter in endometrial carcinoma development [PDF]

, 1999
Yong Zhou, Hidenori Kato, Dan Shan, Rieko Minami, Sohei Kitazawa, Takao Matsuda, Takahiro Arima, J. Carl Barrett, Norio Wake   +8 more
openalex   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas [PDF]

, 1998
Manel Esteller, Ross L. Levine, Stephen B. Baylin, Lora H. Ellenson, James G. Herman   +4 more
openalex   +1 more source

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Cell Proliferation, EarlyView.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen, Chenghao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo   +4 more
wiley   +1 more source

Mutations of the β‐Catenin Gene in Endometrial Carcinomas [PDF]

, 1999
Kanji Kobayashi, Satoru Sagae, Yoshihiro Nishioka, Takashi Tokino, Ryuichi Kudo   +4 more
openalex   +1 more source