SMURF1 Regulates CTCF‐HOXA10 Axis and Promotes Tumor Progression in Nasopharyngeal Carcinoma
Our study showed that SMURF1 was significantly upregulated in nasopharyngeal carcinoma (NPC) and promoted tumor progression and SMURF1 promoted K48‐linked ubiquitination degradation of CTCF. ABSTRACT The aberrant upregulation of Homeobox A10 (HOXA10) has been implicated in the progression of nasopharyngeal carcinoma (NPC), but the mechanisms driving ...
Ying Jin +5 more
wiley +1 more source
Adipose-derived stem cell exosomes promote endometrial carcinoma progression via MAGED4B/CDH1/EMT axis. [PDF]
Li Y +6 more
europepmc +1 more source
L1CAM Promotes the Infiltrative Properties of Patient‐Derived Glioblastoma Cells
In vivo validation of L1CAM‐mediated GBM infiltration. Orthotopic transplantation of L1CAM‐expressing GBM cells into mouse brains demonstrated that L1CAM significantly promotes tumor cell infiltration and expansion in the brain parenchyma, confirming its critical role in the aggressive progression of GBM.
Asako Katsuma +10 more
wiley +1 more source
Type II endometrial cancers with minimal, non-invasive residual disease on final pathology: What should we do next? [PDF]
Cripe, James C +8 more
core +1 more source
Recurrent endometrial carcinoma with immune-mediated thrombocytopenia following durvalumab: A case report. [PDF]
Sakakibara A +7 more
europepmc +1 more source
ABSTRACT Aims Observational studies show metformin use associated with lower cancer risk, although experimental evidence is inconsistent. To provide genetic validation for repositioning of metformin in cancer prevention, we assessed genetically proxied effects of putative metformin targets on cancer outcomes using a drug‐target Mendelian randomization (
Xingyu Shen +7 more
wiley +1 more source
Characterization of T cell markers in endometrial carcinoma through single-cell RNA sequencing. [PDF]
Zhao M, Zhou L.
europepmc +1 more source
Editorial Expression of Concern: P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling [PDF]
Kiyosumi Shibata +6 more
openalex +1 more source
SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation
ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
wiley +1 more source

