Results 61 to 70 of about 729,992 (290)

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Undifferentiated endometrial carcinoma diagnosed during perimenopausal hormone therapy: a case report and literature review

Frontiers in Oncology
Uterine corpus endometrial carcinoma, one of the three most frequent cancers of the female reproductive system, primarily affects women who are perimenopausal or postmenopausal. Moreover, it is an epithelial cancer that develops in the endometrium, which
Ying Wang, Yu-Tong Zheng, Ling Zhang, Xue-Quan Cao, Zhu Lin, Hong-Yu Liu, Qiong-Ying Hu   +6 more
doaj   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Androgen receptor expression in endometrial carcinoma and its correlation with clinicopathologic features

BMC Research Notes, 2018
Objectives Recent evidence suggests a role of androgen receptor expression as a prognostic and therapeutic biomarker in endometrial carcinoma, therefore in the present study we aimed to evaluate the frequency of androgen expression in different subtypes ...
Atif Ali Hashmi, Zubaida Fida Hussain, Amna Qadri, Muhammad Irfan, Sahar Ramzan, Naveen Faridi, Amir Khan, Muhammad Muzzammil Edhi   +7 more
doaj   +1 more source

Apatone® induces endometrioid ovarian carcinoma (MDAH 2774) cells to undergo karyolysis and cell death by autoschizis: A potent and safe anticancer treatment [PDF]

, 2015
Ovarian cancers are still the most lethal gynecologic malignancy. As a novel strategy against this poor outcome cytotoxic alterations induced by a pro-oxidant treatment on human ovarian endometrioid carcinoma (MDAH 2774) cells are revisited by using ...
Gilloteaux, Jacques, Jacques Gilloteaux, Deborah Neal, James M. Jamison, Summers, J.L., Lau, H. Lee, Gourari, Ioulia, H. Lee Lau, J.L. Summers, Summers, J. L., Neal, Deborah, Jamison, James M., Ioulia Gourari   +12 more
core   +1 more source

E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions

Journal of the Egyptian National Cancer Institute, 2014
Background: Loss of E-cadherin is a critical step for development and progression of malignant tumors. CD10; a marker of non-neoplastic and neoplastic endometrial stroma, is associated with aggressiveness of many epithelial malignancies.
Ahmed R.H. Ahmed, Eman M.S. Muhammad
doaj   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma. [PDF]

Cell Prolif
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Guo W, Liu T, Ren R, Li N, Zhang W, Si J, Piao Y, Hu Y.   +7 more
europepmc   +2 more sources

Imaging in endometrial carcinoma

Indian Journal of Radiology and Imaging, 2015
AbstractEndometrial carcinoma (EC) is the most common gynecologic malignancy in the United States. Prognosis depends on patient age, histological grade, depth of myometrial invasion and/or cervical invasion, and the presence of lymph node metastases. Although EC is staged surgically according to the International Federation of Gynecology and Obstetrics
Silvana C Faria, Tara Sagebiel, Aparna Balachandran, Catherine Devine, Chandana Lal, Priya R Bhosale   +5 more
openaire   +3 more sources

Results of Postoperative Treatments in View of the Surgical Stage of Uterine Endometrial Carcinoma [PDF]

, 1997
Background : The indications for and the optimal mode of adjuvant therapy in surgically operated endometrial cancer patients have not yet been established. We studied the indications for the postoperative treatment of endometrial carcinoma patients based
Moriyama, Shingo, Ishimaru, Tadayuki, Nakajima, Hisayoshi, Sakai, Hidetaka, Yamabe, Tooru   +4 more
core  

Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells [PDF]

, 2011
Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog
Poutanen, Matti, Henriet, Patrick, Giulia Grimaldi, Poutanen, Matti,, Steel, Jennifer H., Steel, Jennifer H, Jan J. Brosens, Matti Poutanen, Brosens, Jan J., Christian, Mark, Brosens, Jan J, Mark Christian, Grimaldi, Giulia, Jennifer H. Steel, Patrick Henriet   +14 more
core   +1 more source