Results 91 to 100 of about 38,327 (229)

Metformin use in prediabetes: A review of evidence and a focus on metabolic features among peri‐menopausal women

Diabetes, Obesity and Metabolism, Volume 27, Issue S3, Page 3-15, June 2025.
Abstract The prevalence of prediabetes has more than doubled over the past two decades. Although hormones associated with the menstrual cycle may offer some protection against diabetes by enhancing insulin sensitivity and suppressing gluconeogenesis, the prevalence of diabetes among women remains high at 10.5%.
Beth Shi Yu Lim, Muzi Chen, Hung‐Yuan Li, Ling‐Jun Li   +3 more
wiley   +1 more source

Single‐cell sequencing reveals a regulatory role of WT1 in mast cell proliferation in endometrial polyps

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
We used single‐cell and bulk RNA sequencing to analyze ectopic endometrial polyps (EPs) and adjacent eutopic endometrial tissues (EUs), identifying alterations in cell composition and transcriptional dynamics. Notably, mast cells showed increased activation with distinct transcriptional changes.
Yu Lin, Yiwen Qi, Yutong Yao, Huan Tong, Lan Chen, Weizhou Song, Guojing Li, Hong Xu, Xiaoying He   +8 more
wiley   +1 more source

How to blow up a massive star [PDF]

, 2016
Unweighted UniFrac distance between benign, hyperplasia, and endometrial cancer cohorts.
Alexis Hokenstad (3575855), Andrea Mariani (495858), Douglas Creedon (3575873), E. Cheek (3575867), Francesco Multinu (3575864), Gary Keeney (3575861), Heidi Nelson (674930), Jun Chen (4238), Marina Walther-Antรณnio (3575876), Nicholas Chia (233775), Tammy Distad (3575870)   +10 more
core   +7 more sources

Association of Endometrial Hyperplasia with Some Risk Factors

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2009
BACKGROUND AND OBJECTIVE: Endometrial cancer is one of the most common invasive gynecologic malignancies. Abnormal uterine bleeding (AUB) is the most common symptom in endometrial hyperplasia. Women with AUB are examined with dilation and curettage (D;C)
R Faraji,, N Esmailpour, B Behfar
doaj  

A physical mechanism of heterogeneity in stem cell, cancer and cancer stem cell [PDF]

, 2019
Heterogeneity is ubiquitous in stem cells (SC), cancer cells (CS), and cancer stem cells (CSC). SC and CSC heterogeneity is manifested as diverse sub-populations with self-renewing and unique regeneration capacity. Moreover, the CSC progeny possesses multiple plasticity and cancerous characteristics.
arxiv   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, Volume 6, Issue 5, May 2025.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Long-term treatment of uterine fibroids with ulipristal acetate [PDF]

, 2014
Objective: To investigate the efficacy and safety of ulipristal acetate (UPA) for long-term treatment of symptomatic uterine fibroids.<p></p> Design: Repeated intermittent open-label UPA courses, each followed by randomized double-blind ...
Bart C.J.M. Fauser, Brown, Busfield, David H. Barlow, Dolan, Donnez, Donnez, Donnez, Donnez, Elke Bestel, Ernest Loumaye, Fiscella, Fiscella, Francisco Vázquez, Gainer, Higham, Higham, Horak, Ian Osterloh, Ioffe, Jacques Donnez, Janssen, Janusz Tomaszewski, Kadir, Kazem Nouri, Kim, Kim, Kouides, Kriplani, Lethaby, Levens, Mehine, Melis, Melzack, Melzack, Mutter, Mutter, Nieman, Olivier Donnez, Philipp, Philippe Bouchard, Pohl, Reid, Santiago Palacios, Scialli, Spies, Spies, Spies, Stewart, Stewart, Takeda, Wallach, Williams, Williams, Zakherah, Zapata   +55 more
core   +1 more source

Hypoxic damage and neovascularization of endometrium in endometrial hyperplasia [PDF]

РМЖ. Мать и дитя, 2019
E.A. Kazachkova, E.L. Kazachkov, A.V. Zatvornitskaya, E.E. Voropaeva South Ural State Medical University, Chelyabinsk, Russian Federation Aim: to assess the effects of hypoxic damage and neovascularization of endometrium in ...
E.A. Kazachkova, E.L. Kazachkov, A.V. Zatvornitskaya, E.E. Voropaeva   +3 more
doaj  

p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation [PDF]

, 2015
p21-activated kinases (Paks) are serine/threonine protein kinases involved in biological events linked to malignant tumor progression. In this study, expression of Pak1, p-Pak2 Ser20, Pak4, pPak4 Ser474 in 21 normal endometrium, 16 hyperplastic ...
Chan, HY, Chan, KKL, Cheung, ANY, Jiang, L, Kong, DS, Liu, S, Ngai, SY, Ngan, HYS, Siu, KY, Wong, ESY   +9 more
core   +1 more source

Diagnostic, prognostic, and predictive importance of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and CA125 in endometrial hyperplasia and carcinoma

Indian Journal of Pathology and Microbiology
Background: Inflammation has an important role in the progression of endometrial carcinoma. Aims: The aim of this study is to find the association between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and CA125 in endometrial ...
Bharti Kumari, Debaditya Haldar, Guddi R. Singh, Sweta Kumari, Sangeeta Pankaj, Rajnikant Prasad   +5 more
doaj   +1 more source