Results 91 to 100 of about 20,476 (195)

Endometrial Stromal Hyperplasia: An Underrecognized Condition

Case Reports in Pathology, 2013
Hyperplasia of the endometrial stroma is a poorly recognized lesion, lacking widespread recognition with most, if not all, such cases sequestrated in the literature as endometrial stromal nodules or low-grade endometrial stromal sarcomas.
Efthimios Sivridis, Gerasimos Koutsougeras, Alexandra Giatromanolaki   +2 more
doaj   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSION OF BCL-2 AND KI-67 BIOMARKERS IN SIMPLE ENDOMETRIAL HYPERPLASIA AS A DIAGNOSTIC TOOL IN IRAQI FEMALE PATIENTS

Клінічна та профілактична медицина
Introduction. Endometrial hyperplasia (EH) is a hyperplastic change or pathologic condition in the glands of the endometrium and stromal structures that line the uterine cavity, and is most often caused by an increase in estrogen and a decrease in ...
Ahlam Shakir Hammood AL-Rubaiawi, Ali Hussein Mohammed Ali AL-Khafaji   +1 more
doaj   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, Volume 104, Issue 6, Page 539-555, June 2026.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Efficacy and Safety of Fixed‐Dose Combinations of Sitagliptin and Empagliflozin as Add‐On to Metformin in Korean Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Multi‐Centre, Placebo‐Controlled, Phase III Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4847-4859, June 2026.
ABSTRACT Background Type 2 diabetes mellitus (T2DM) is a progressive, multi‐organ disorder that often requires intensive combination therapy. This Phase III, randomised, double‐blind, placebo‐controlled study evaluated the efficacy and safety of two fixed‐dose combinations (FDCs) of sitagliptin 100 mg with empagliflozin 10 mg (DW1026C1) or ...
Soo Lim, Tae Nyun Kim, Ji Oh Mok, Choon Hee Chung, You Cheol Hwang, Ho Chan Cho, Jong Chul Won, Eonju Jeon, Eun Seok Kang, Ki Young Lee, Chong Hwa Kim, Soo Heon Kwak, Cheol Young Park, Kang Seo Park, Sang Yong Kim, Jae Hyuk Lee, Soon Hee Lee, Dong Hyeok Cho, Hyuk‐Sang Kwon, Kyung Ah Han   +19 more
wiley   +1 more source

Pathogenetic aspects of recurrent endometrial hyperplasia without atypia in women of childbearing age

Клинический разбор в общей медицине
Aim: to determine the most informative immunohistochemical markers of recurrent endometrial hyperplasia without atypia in women of childbearing age. Methods.
Mekan R. Orazov , Liudmila M. Mikhaleva , Marina B. Khamoshina, Irina A. Mullina , Yulia S. Artemenko   +4 more
doaj   +1 more source

Effect of the Mutual Interaction of GPNMB and LPAR1 on Cellular Motility and Tumorigenicity in Mammary Epithelial Cells

Pathology International, Volume 76, Issue 6, June 2026.
GPNMB and LPAR1 form a positive feedback loop enhancing LPA signaling. LPA–LPAR1 activates RhoA–ROCK, driving actin reorganization and cell motility. GPNMB–LPAR1 signaling promotes tumorigenic potential. ABSTRACT Glycoprotein non‐metastatic melanoma protein B (GPNMB) is a poor prognostic factor, which is highly expressed in many types of malignant ...
Minori Kimura, Yukari Okita, Erina Iwabuchi, Xinzhu Hong, Yumu Ichikawa, Manar A. Elhinnawi, Hironobu Sasano, Mitsuyasu Kato   +7 more
wiley   +1 more source

Endometrial Atypical Hyperplasia and Risk of Endometrial Cancer

Diagnostics
Endometrial atypical hyperplasia (EAH) is a premalignant condition with a substantial risk of progression to endometrial cancer (EC), with the endometrioid subtype being the most common. EAH is characterized by abnormal endometrial gland proliferation and cellular atypia, often resulting from prolonged unopposed estrogen exposure.
An-Ju Chou, Ruo-Shi Bing, Dah-Ching Ding
openaire   +3 more sources

Model Predicting the Risk of Endometrial Hyperplasia Developing into Endometrial Cancer

Journal of Inflammation Research
Jing Su,1,* Lina She,1,* Yang Fan,1 Honghong Wang,2 Qiaorui Zhang,1 Jiao Zhang,1 Hongyun Ma1 1Department of Obstetrics and Gynecology, People’s Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan, People’s Republic of ...
Su J, She L, Fan Y, Wang H, Zhang Q, Zhang J, Ma H   +6 more
doaj  

Immunohistochemical Assessment of YAP1 Expression in Endometrial Hyperplasia with and without Atypia

Haseki Tıp Bülteni
Aim: Endometrial hyperplasia, particularly when accompanied by atypia, is considered a well-established precursor of endometrial carcinoma. Yes-associated protein 1 (YAP1), a key effector of the Hippo signaling pathway, plays a crucial role in the ...
Alp Koray Kinter, Ozer Oztekin, Nagihan Yalcın, Savas Ozdemir, Refaettin Sahin, Gulden Turan, Alpaslan Kaban   +6 more
doaj   +1 more source