Results 11 to 20 of about 236,724 (287)

Molecular Profiling of Endometrial Malignancies

Obstetrics and Gynecology International, 2010
Molecular profiling of endometrial neoplasms reveals genetic changes in endometrial carcinomas that support the dualistic model, in which type I carcinomas are estrogen-dependent, low grade lesions and type II carcinomas are nonestrogen dependent and ...
Norasate Samarnthai, Kevin Hall, I-Tien Yeh   +2 more
doaj   +2 more sources

Cancer-associated mutations in endometriosis reframe a benign disease through molecular oncology. [PDF]

Mol Oncol
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Mujacic C, Vitale MC, Siino R, Di Giovanni E, Ferrante Bannera C, Di Marco E, Gottardo A, Russo TDB, Barraco N, Perez A, Gristina V, Galvano A, Badalamenti G, Russo A, Bazan V, Incorvaia L.   +15 more
europepmc   +2 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer-relevant paralog interplay. [PDF]

Mol Oncol
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Pinault M, Heraud C, Oliveira MC, Neaud V, Valesco V, Prouzet-Mauleon V, Turcq B, Dupuy JW, Raymond AA, Croce S, Saltel F, Lagrée V, Moreau V.   +12 more
europepmc   +2 more sources

Genetic Markers and Predisposition to Endometrial Neoplasms: A Systematic Review

OBJECTIVE: To identify genetic markers and understand their influence on the predisposition to endometrial neoplasms. METHODS: A systematic review was conducted between June and July 2024, following the Preferred Reporting Items for Systematic Reviews ...
Ana Clara Souza Dias Buffoni, Mario Cesar Tessarolo Saquetto, Fabiane Monteiro de Carvalho Souza Gomes, Lucas Sousa Pontes, Ana Paula Merscher Zanoni   +4 more
core   +6 more sources

Ambulatory diagnosis of endometrial pathology [PDF]

, 2003
The aim of this thesis was to determine the diagnostic accuracy of outpatient endometrial evaluation using endometrial biopsy (EB), ultrasound scan (USS) and hysteroscopy (OPH) by conducting systematic quantitative reviews of the published literature ...
Clark, Thomas Justin
core   +7 more sources

Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations [PDF]

, 2006
Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by ...
Bartnik, Ewa, Lorenc, Anna, Bryk, Jarek, Ewa Bartnik, Semczuk, Andrzej, Putowski, Lechoslaw, Anna Lorenc, Miotla, Pawel, Lechoslaw Putowski, Jaroslaw Bryk, Konrad Futyma, Andrzej Semczuk, Futyma, Konrad, Pawel Miotla   +13 more
core   +1 more source

Mutations and amplification of oncogenes in endometrial cancer [PDF]

, 1999
Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
Niederacher, Dieter, Cho, Yong-Jig, An, Han-Xiang, Beckmann, Matthias W., Hantschmann, Peer, Bender, Hans G.   +5 more
core   +1 more source

Primary endometrial B-Cell lymphoma: Rare etiology of abnormal uterine bleeding and potential nonsurgical therapy

Radiology Case Reports, 2015
We present a case of primary endometrial B-cell lymphoma, pathologically confirmed. The patient is a 68-year-old female with postmenopausal bleeding. Ultrasound revealed endometrial thickening and was followed up with endometrial biopsy.
Jonathan Revels, DO, Bradley Monteforte, BS, David Malin, MD   +2 more
doaj   +1 more source

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors [PDF]

, 2013
Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely ...
Annemarie Samalecos, Annemarie Samalecos (275635), Anja Wolf (275636), Weimar, C.H., Philipp Velicky, Michelle Kruse (275634), Wolf Anja, Kruse Michelle, Nick S Macklon, Macklon Nick S., Charlotte H. E. Weimar (148304), Nick S. Macklon (148320), Velicky Philipp, Weimar Charlotte H. E., Maren Schwenke, Philipp Velicky (275632), Gellersen Birgit, Schwenke, M., Maren Schwenke (275628), Knöfler Martin, Schwenke Maren, Gellersen, B., Samalecos Annemarie, Wolf, A., Bamberger, A.M., Martin Knöfler, Anja Wolf, Bamberger Ana-Maria, Michelle Kruse, Charlotte H E Weimar, Birgit Gellersen (148307), Velicky, P., Ana-Maria Bamberger, Ana-Maria Bamberger (275637), Kruse, M., Macklon, N.S., Birgit Gellersen, Knofler, M., Samalecos, A., Martin Knöfler (275630)   +39 more
core   +1 more source

Endometrial cancer - reduce to the minimum. A new paradigm for adjuvant treatments?

Radiation Oncology, 2011
Background Up to now, the role of adjuvant radiation therapy and the extent of lymph node dissection for early stage endometrial cancer are controversial.
Scheithauer Heike R, Schulz Diana S, Belka Claus   +2 more
doaj   +1 more source