Results 41 to 50 of about 511,190 (325)

ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

Nature Communications, 2019
PIK3CA mutations and ARID1A loss co-exist in endometrial neoplasms. Here, the authors show that these co-mutations drive gene expression profiles correlated with differential chromatin accessibility and ARID1A binding in the endometrial epithelium ...
Mike R. Wilson, Jake J. Reske, Jeanne Holladay, Genna E. Wilber, Mary Rhodes, Julie Koeman, Marie Adams, Ben Johnson, Ren-Wei Su, Niraj R. Joshi, Amanda L. Patterson, Hui Shen, Richard E. Leach, Jose M. Teixeira, Asgerally T. Fazleabas, Ronald L. Chandler   +15 more
doaj   +1 more source

Immunotherapy in gynecological cancers

Exploration of Targeted Anti-tumor Therapy, 2021
Immunotherapy has changed the natural history of several malignancies that, a decade ago, had a very poor prognosis, such as lung cancer and melanoma.
Domenica Lorusso, Valentina Ceni, Gennaro Daniele, Antonella Pietragalla, Vanda Salutari, Margherita Muratore, Camilla Nero, Francesca Ciccarone, Giovanni Scambia   +8 more
doaj   +1 more source

Endometrial thickness cut-off value by transvaginal ultrasonography for screening of endometrial pathology in premenopausal and postmenopausal women [PDF]

Obstetrics & Gynecology Science, 2019
ObjectiveTo assess the clinical usefulness and diagnostic accuracy of ultrasonographic measurement of endometrial thickness (ET) in women with endometrial hyperplasia or cancer (EH+).MethodsThis retrospective cohort study included 29,995 consecutive ...
Yu Ran Park, Shin Wha Lee, Yeongsin Kim, In Young Bae, Hong-Kyu Kim, Jaewon Choe, Yong-Man Kim   +6 more
doaj   +1 more source

Association of Membranous WNT-1 and Nuclear mTOR with Endometrial Cancer Grade

International Journal of Molecular Sciences, 2023
Endometrial cancer remains a common cancer affecting the female reproductive system. There is still a need for more efficient ways of determining the degree of malignancy and optimizing treatment.
Miłosz Pietrus, K. Pityński, Marcin Waligóra, K. Milian-Ciesielska, A. Ludwin, Maciej W. Socha, K. Skrzypek   +6 more
semanticscholar   +1 more source

A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: Immunohistochemical and molecular studies and review of the literature

World Journal of Surgical Oncology, 2012
Background As a rule, endocervical tumours with signet-ring cell are classed as metastatic extra-genital neoplasms. In a patient aged 45 years, we describe primary cervical signet-ring cell carcinoma (PCSRCC) characterized by prominent endometrial and ...
Giordano Giovanna, Pizzi Silvia, Berretta Roberto, D'Adda Tiziana   +3 more
doaj   +1 more source

The Role of Microbiota in the Immunopathogenesis of Endometrial Cancer

International Journal of Molecular Sciences, 2022
The female reproductive tract hosts a specific microbiome, which plays a crucial role in sustaining equilibrium and good health. In the majority of reproductive women, the microbiota (all bacteria, viruses, fungi, and other single-celled organisms within
M. Sobstyl, Peet Brecht, Anna Sobstyl, Paulina Mertowska, E. Grywalska   +4 more
semanticscholar   +1 more source

Data Set for the Reporting of Endometrial Cancer: Recommendations From the International Collaboration on Cancer Reporting (ICCR)

International Journal of Gynecological Pathology, 2022
Endometrial cancer is one of the most common cancers among women. The International Collaboration on Cancer Reporting (ICCR) developed a standardized endometrial cancer data set in 2011, which provided detailed recommendations for the reporting of ...
X. Matías-Guiu, C. Selinger, L. Anderson, N. Buza, L. H. Ellenson, Oluwole Fadare, R. Ganesan, P. Ip, J. Palacios, C. Parra‐Herran, M. Raspollini, R. Soslow, H. M. Werner, S. Lax, W. McCluggage   +14 more
semanticscholar   +1 more source

Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma

American Journal of Surgical Pathology, 2022
With the widespread application of next-generation sequencing, the genetic landscape of uterine mesenchymal neoplasms has been evolving rapidly to include several recently identified fusion genes.
A. Agaimy, B. Clarke, David L. Kolin, Cheng-Han Lee, Jen-Chieh Lee, W. McCluggage, Patrik Pöschke, R. Stoehr, D. Swanson, G. Turashvili, M. Beckmann, A. Hartmann, C. Antonescu, B. Dickson   +13 more
semanticscholar   +1 more source

Histopathology of Endometrial Stromal Sarcoma with Emphasis on Immunohistochemistry Marker Expression: Report of Three Cases

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Endometrial stromal tumors are rare uterine mesenchymal neoplasms. Endometrial stromal sarcomas (ESSs) are of endometrial stromal origin that accounts for approximately 1% of all uterine malignant neoplasms.
Narayanamoorthy Keerthyraj, Vigneswaramoorthi Vinayagamoorthi, Erli Amel Ivan, V Sriram, Govindasamy Revathi, Ramya Gandhi   +5 more
doaj   +1 more source

Low grade endometrial stromal sarcoma – A series of 4 cases and review of relevant literature

Journal of Pathology of Nepal, 2015
Endometrial stromal tumors are rare uterine malignancies composed of cells resembling those of proliferative endometrial stroma. Because of their indistinct clinical and radiological features, these malignancies are very rarely diagnosed preoperatively ...
P Vijayan, LM Ilias, A Ponniah, BA Mohammed   +3 more
doaj   +1 more source