Results 231 to 240 of about 244,422 (325)

Beyond the chaos: How architecture structures tumour biology

open access: yesThe FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner   +3 more
wiley   +1 more source

SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
wiley   +1 more source

HDAC3 Regulates Transcriptional Networks Governing Decidualization

open access: yesThe FASEB Journal, Volume 40, Issue 8, 30 April 2026.
HDAC3 orchestrates transcriptional programs essential for uterine decidualization. Loss of HDAC3 disrupts cytoskeletal organization, metabolic signaling, and oxidative stress responses, impairing stromal cell differentiation and decidualization. These alterations compromise uterine receptivity and result in failed embryo implantation.
Loan Thi Kim Nguyen   +5 more
wiley   +1 more source

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