Results 111 to 120 of about 722,347 (248)

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Case Report: Two instances of lung metastasis in low-grade endometrial stromal sarcoma

Frontiers in Oncology
BackgroundLow-grade endometrial stromal sarcoma (LGESS) with pulmonary metastasis is a rare malignant mesenchymal tumor. LGESS is composed of cells resembling proliferative endometrial stromal cells.
Anying Long, Xiaoxue Tian, Yao Li, Shuai Luo, Jinjing Wang   +4 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Low-grade endometrial stromal sarcoma [PDF]

, 2018
Se trata de una paciente de 25 años con historia de salud anterior e historia obstétrica de un embarazo y un parto. En esta ocasión acudió a consulta por presentar dolor bajo vientre desde hacía tres meses y expulsión por la vagina de un material muy ...
Fernández Manzo, José de la Caridad, Rodríguez Santos, Irene Carmen, Batule Llanes, Doris María, Bouza Jorge, Darlene, González Valcárcel, Kenia, Alba Turiño, Osmani, Fernández Gutiérrez, José, Iglesias Yera, Armando Eugenio, Anoceto Armiñana, Eliecer, Cabrera Abreu, Yarisleidy   +9 more
core  

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Folate receptor alpha (FRα) expression in tubo‐ovarian and endometrial tumors: a study of 923 cases

The Journal of Pathology: Clinical Research
Folate receptor alpha (FRα) is a promising therapeutic target due to its high expression in several tumor types and its rare expression in healthy tissue.
Isabela Töltési, Kristýna Němejcová, Michaela Kendall Bártů, Romana Vránková, David Cibula, Pavel Fabian, Filip Frühauf, Jitka Hausnerová, Jan Laco, Gábor Méhes, Zuzana Špůrková, Marián Švajdler, Radoslav Matěj, Pavel Dundr   +13 more
doaj   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

Cell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo, Tianxiang Liu, Runling Ren, Na Li, Wenwen Zhang, Jingwen Si, Yongjun Piao, Yuanjing Hu   +7 more
wiley   +1 more source

An interpretable deep learning model for predicting endometrial cancer molecular subtypes from H&E-stained slides

npj Precision Oncology
The molecular subtype of endometrial cancer is important for predicting prognosis and treatment effectiveness. This study aimed to develop an interpretable deep learning model based on H&E-stained whole slide images (WSIs) to predict the molecular ...
Qinhao Guo, Haoyu Cui, Yangyang Zhang, Shaoxian Tang, Weicheng Yan, Xiaoyan Zhou, Hongmei Ding, Jinhua Zhou, Xingzhu Ju, Zheng Feng, Jun Zhu, Fang Bai, Yanping Zhong, Haiming Li, Jun Xu, Xiaohua Wu, Xiangxue Wang, Hao Wen   +17 more
doaj   +1 more source

Imaging in Uncommon Uterine Malignancies

Journal of Gastrointestinal and Abdominal Radiology
This review provides a comprehensive overview of the classification and imaging characteristics of uncommon uterine malignancies, guided by the latest World Health Organization classification of female genital tumors (fifth edition, 2020). We discuss the
Divij Agarwal, Smita Manchanda, Ankita Aggarwal, Ekta Dhamija, Seema Singhal, Jyoti Meena   +5 more
doaj   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source