Results 71 to 80 of about 30,534 (142)

Obesity, white adipose tissue and cancer

The FEBS Journal, Volume 292, Issue 9, Page 2189-2207, May 2025.
White adipose tissue (WAT) is essential for energy balance and hormone regulation. In obesity, WAT becomes dysfunctional, leading to inflammation and other changes that promote different stages of carcinogenesis. This review explores how unhealthy WAT under obese conditions supports carcinoma growth through both systemic effects and modulation of the ...
Estel Solsona‐Vilarrasa, Karen H. Vousden   +1 more
wiley   +1 more source

High Prevalence of Platelet Function Disorders in Women Referred for Surgical Management of Refractory Heavy Menstrual Bleeding

Haemophilia, EarlyView.
ABSTRACT Introduction Heavy menstrual bleeding (HMB) is a common presenting symptom in women with bleeding disorders, yet haemostatic testing is sometimes overlooked, even when refractory HMB requires surgical intervention. Aim To determine the prevalence of bleeding disorders in women referred for surgical management of HMB and investigate screening ...
Alison Delaney, Evangelos I. Kritsotakis, Kevin Horner, Steve Kitchen, Jennifer Sedcole, Ted Baxter, Rhona M. Maclean, Michael Makris, Clare V. Samuelson   +8 more
wiley   +1 more source

Ossifying fibromyxoid tumours with lipomatous and cartilaginous differentiation: A diagnostic pitfall

Histopathology, Volume 86, Issue 6, Page 891-899, May 2025.
Six cases of ossifying fibromyxoid tumour with lipomatous and cartilaginous differentiation are presented. Even though the clinical presentation and immunoprofile of these cases are concordant with classic ossifying fibromyxoid tumour they may provide significant diagnostic difficulty, given the rarity of these histopathological findings.
Natálie Klubíčková, Steven Billings, Josephine K T Dermawan, Jeremy F Molligan, Karen Fritchie   +4 more
wiley   +1 more source

Prognostic values of molecular subtypes and SWI/SNF protein expression in de‐differentiated/undifferentiated endometrial carcinoma

Histopathology, Volume 86, Issue 7, Page 1053-1063, June 2025.
Our study characterised the molecular subtypes and SWI/SNF protein expression in de‐differentiated/undifferentiated endometrial carcinoma (DD/UDEC) assembled at one single institution. We demonstrated that while MMR, p53 and SWItch/sucrose non‐fermentable (SWI/SNF) protein expression status did not provide prognostic value, all molecular subtypes of DD/
Chae Young Shin, Bengul Gokbayrak, Valerie L Tao, Noorah Almadani, Eunice S Li, Rebecca Ho, Felix KF Kommoss, Jutta Huvila, Derek Chiu, Samuel Leung, Basile Tessier‐Cloutier, David G Huntsman, C Blake Gilks, Jessica N McAlpine, Lynn Hoang, Yemin Wang   +15 more
wiley   +1 more source

Activin a regulates vascular formation and stabilization in direct coculture of dental pulp stem cells and endothelial cells

International Endodontic Journal, EarlyView.
Abstract Aim Establishing functional circulation on time is crucial to dental pulp tissue regeneration. Mesenchymal stem cells (MSCs) could act as mural cells to stabilize newly formed blood vessels, accelerating anastomosis. Our preliminary study found that direct coculture of dental pulp stem cells (DPSCs) and human umbilical vein endothelial cells ...
Jialin Zhong, Yuchen Zhang, Shulan Lin, Jun Kang, Mingxin Hu, Junqing Liu, Ying Chen, Qianzhou Jiang, Chengfei Zhang   +8 more
wiley   +1 more source

Long-term results of a multicenter SAKK trial on high-dose ifosfamide and doxorubicin in advanced or metastatic gynecologic sarcomas [PDF]

, 2017
Background: Dose intensive chemotherapy has not been tested prospectively for the treatment of gynecologic sarcomas. We investigated the antitumor activity and toxicity of high-dose ifosfamide and doxorubicin, in the context of a multidisciplinary ...
Cerny, T., Dietrich, D., Fey, M., Honegger, H. P., Jundt, G., Leyvraz, S., Lissoni, A., Sessa, C., Zweifel, M.   +8 more
core  

PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

Immunology, EarlyView.
Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley   +1 more source

Morphological features of serosa‐associated lymphoid clusters of the rat parietal pleura: Exploring a relatively unexplored system

Journal of Anatomy, EarlyView.
This study explored serosa‐associated lymphoid clusters in rat pleura (pSALCs), identifying their distribution and categorizing them into four morphological types. Data provided by this study form the basis for future morphological comparisons with humans and the potential to extrapolate functional characteristics of pSALCs from experimental studies in
Rosa E. Lagerwerf, Claire Mackaaij, Frieke Kuper, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +4 more
wiley   +1 more source

Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report [PDF]

, 2017
Babb, Sheri, Divine, Laura M, Hagemann, Ian S, Mullen, Mary M, Powell, Matthew A   +4 more
core   +3 more sources

Proposal for a New Classification of Rare Cancers Adopting Updated Histological Tumor Types

Pathology International, EarlyView.
We propose a new rare cancer classification system using the updated International Classification of Diseases for Oncology 3.2 coding system and the World Health Organization Classification of Tumors 5th edition. This list could serve as a diagnostic classifier to reliably distinguish various rare cancers for clinical applications.
Ryoko Rikitake, Yasushi Yatabe, Yoko Yamamoto, Tatsunori Shimoi, Shintaro Iwata, Yasushi Goto, Yu Mizushima, Akira Kawai, Takahiro Higashi   +8 more
wiley   +1 more source