Results 81 to 90 of about 22,080 (229)

Differences between mitotically old and young endometrial tumors

The Journal of Pathology, EarlyView.
Abstract Human tumors likely differ in their mitotic ages, reflecting how many divisions elapse between the final tumor progenitor cell and surgical removal. We used a rapidly fluctuating CpG (fCpG) methylation clock to infer relative endometrial adenocarcinomas (EAC) mitotic ages.
Kellie Kim, Darryl Shibata
wiley   +1 more source

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, EarlyView.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

Case Report: Two instances of lung metastasis in low-grade endometrial stromal sarcoma

Frontiers in Oncology
BackgroundLow-grade endometrial stromal sarcoma (LGESS) with pulmonary metastasis is a rare malignant mesenchymal tumor. LGESS is composed of cells resembling proliferative endometrial stromal cells.
Anying Long, Xiaoxue Tian, Yao Li, Shuai Luo, Jinjing Wang   +4 more
doaj   +1 more source

Diagnosis of Endometrial Stromal Tumors [PDF]

American Journal of Clinical Pathology, 2014
Sten Stemme, Mehran Ghaderi, Joseph W. Carlson   +2 more
openaire   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

Folate receptor alpha (FRα) expression in tubo‐ovarian and endometrial tumors: a study of 923 cases

The Journal of Pathology: Clinical Research
Folate receptor alpha (FRα) is a promising therapeutic target due to its high expression in several tumor types and its rare expression in healthy tissue.
Isabela Töltési, Kristýna Němejcová, Michaela Kendall Bártů, Romana Vránková, David Cibula, Pavel Fabian, Filip Frühauf, Jitka Hausnerová, Jan Laco, Gábor Méhes, Zuzana Špůrková, Marián Švajdler, Radoslav Matěj, Pavel Dundr   +13 more
doaj   +1 more source

Indications and Efficacy of Progestogen‐Monotherapy as Menopause Hormone Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen monotherapy, though historically underutilized, represents a viable alternative in this population. This narrative review
Chloe Thomas, Olivia Carere, Lauren Clarfield, Michelle Jacobson   +3 more
wiley   +1 more source

An interpretable deep learning model for predicting endometrial cancer molecular subtypes from H&E-stained slides

npj Precision Oncology
The molecular subtype of endometrial cancer is important for predicting prognosis and treatment effectiveness. This study aimed to develop an interpretable deep learning model based on H&E-stained whole slide images (WSIs) to predict the molecular ...
Qinhao Guo, Haoyu Cui, Yangyang Zhang, Shaoxian Tang, Weicheng Yan, Xiaoyan Zhou, Hongmei Ding, Jinhua Zhou, Xingzhu Ju, Zheng Feng, Jun Zhu, Fang Bai, Yanping Zhong, Haiming Li, Jun Xu, Xiaohua Wu, Xiangxue Wang, Hao Wen   +17 more
doaj   +1 more source

Imaging in Uncommon Uterine Malignancies

Journal of Gastrointestinal and Abdominal Radiology
This review provides a comprehensive overview of the classification and imaging characteristics of uncommon uterine malignancies, guided by the latest World Health Organization classification of female genital tumors (fifth edition, 2020). We discuss the
Divij Agarwal, Smita Manchanda, Ankita Aggarwal, Ekta Dhamija, Seema Singhal, Jyoti Meena   +5 more
doaj   +1 more source