Results 81 to 90 of about 30,534 (142)

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

open access: yesInternational Journal of Cancer, Volume 157, Issue 2, Page 371-383, 15 July 2025.
What's new? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita   +12 more
wiley   +1 more source

Mutated TP53 is a marker of increased VEGF expression: analysis of 7,525 pan-cancer tissues. [PDF]

open access: yes, 2020
Anti-angiogenic therapies are an important class of anti-cancer treatment drugs. However, their efficacy is limited to certain tumors and would benefit from identifying a biomarker predictive of therapeutic response.
Boichard, Amélie   +2 more
core  

Bilateral Ovarian Hemangiomas Presenting With Abnormal Uterine Bleeding: A Rare Case Report

open access: yesClinical Case Reports, Volume 13, Issue 6, June 2025.
ABSTRACT Ovarian hemangiomas are rare benign vascular tumors that can present with abnormal uterine bleeding and mimic malignant ovarian lesions. Imaging may be inconclusive, and histopathology remains essential for diagnosis. This case highlights the importance of considering ovarian hemangiomas in the differential diagnosis of pelvic masses to ensure
Ensiyeh Bahadoran, Fatemeh SamieeRad
wiley   +1 more source

Endometriosis‐derived exosomes encapsulated miR‐196a‐5p mediate macrophage polarization through regulation of the Hippo pathway

open access: yesJournal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Encapsulation of miR‐196a‐5p mimic in serum‐derived exosomes from patients with endometriosis by electrotransfection: exosomes encapsulated with miR‐196a‐5p are phagocytosed by macrophages and release miR‐196a‐5p; miR‐196a‐5p activates the Hippo pathway and promotes macrophage M1‐type polarization, thereby inhibiting 12Z cell metastasis.
Bin Lu, Qixiang Huang, Yanyu Zhong
wiley   +1 more source

The Potential Role of Egg‐Derived Xeno‐miRs in Chemotherapy Response: An In Silico Approach

open access: yesFood Science &Nutrition, Volume 13, Issue 6, June 2025.
Dietary microRNAs (Xeno‐miRs), especially those homologous to human miRNAs found in animal‐based foods, may influence chemotherapy responses across cancer types. This study highlights the underexplored potential of human homolog egg‐derived Xeno‐miRs as biomarkers and therapeutic targets.
Berkcan Doğan
wiley   +1 more source

Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

open access: yesMedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and
Xin Wang, Jie Chen, Hubing Shi
wiley   +1 more source

Attribution of ghrelin to cancer; Attempts to unravel an apparent controversy [PDF]

open access: yes, 2019
Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute
Khani, Leila   +5 more
core   +1 more source

Myeloid‐Derived Suppressor Cells in Cancer: Mechanistic Insights and Targeted Therapeutic Innovations

open access: yesMedComm, Volume 6, Issue 6, June 2025.
This review summarizes the origin and biological characteristics of MDSCs, focusing on their immunological and nonimmunological roles in tumor progression. It also discusses the prognostic value of MDSCs and the latest advancements in clinical trials, highlighting the potential of emerging therapeutic strategies for cancer treatment and drug ...
Tianying Hu   +12 more
wiley   +1 more source

Primary Leiomyosarcoma of Ovary [PDF]

open access: yes, 2009
Primary ovarian leiomyosarcomas is a rare neoplasm which comprises less than 3% of ovarian tumors. Their origin, etiology, histologic features, clinical behavior, and optimal treatment are still obscure.
Kaul, R, Sharma, J
core  

Transcriptional Profiling of SSEA‐1+ Endometrial Epithelial Progenitor Cells Highlights Their Role in Endometrial Regeneration, Remodeling, and Homeostasis

open access: yesThe FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Sampling, isolation, cell sorting and microarray analysis of SSEA‐1+ endometrial epithelial progenitor cells. Gene expression data was analysed using computational pathway analysis methods and internally validated using real‐time quantitative PCR and externally validated using dual‐label immunofluorescence and endometrial epithelial organoid models ...
Hannan Al‐Lamee   +10 more
wiley   +1 more source

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