Results 81 to 90 of about 35,905 (266)

Targeting RTK signaling pathways in cancer [PDF]

, 2015
The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding.
Regad, T
core   +1 more source

Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis [PDF]

, 2017
The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde menstruation is a physiological process that affects 90% of women, while ...
Acien, Acin, Acién, Agic, Annabi, Annunziata, Antonio Simone Laganà, Bao, Bartol, Bartol, Batt, Benchaouir, Benson, Berthelsen, Bodnar, Bouquet de Jolinière, Branford, Bratincsák, Brenner, Brown, Buck Louis, Bukulmez, Bulun, Bulun, Bulun, Burel, Burke, Burney, Butticè, Bénazéraf, Bürglin, Capellini, Cervelló, Chwalisz, Collins, Colonese, Crispi, Cunha, Cunha, Cunha, Cunha, Cutler, Das, De Paiva, Delbandi, Deschamps, Du, Dubrulle, Dubrulle, Dunlap, Dunselman, D’Amour, D’Amour, Ebert, Eda Vrtačnik-Bokal, Evseenko, Fedele, Ferretti, Francesca Maria Salmeri, Fu, Fujii, Fukunaga, Funayama, Gan, Gargett, Gargett, Gargett, Giannarini, Giudice, Gould, Gray, Guo, Harada, Harley, Hayashi, Helena Ban Frangež, Herrgen, Ho, Hoang-Ngoc, Hooiveld, Hubbard, Ikoma, Jeong, Jones, Jones, Jordan, Kagami, Kato, Korkmaz, Kuhl, Kyamidis, Laganà, Laganà, Laganà, Laganà, Laganà, Laganà, Lagarkova, LaRonde-LeBlanc, Lauchlan, Lee, Li, Lily Stojanovska, Lin, Liu, Liu, MacDonald, Mallo, Maniglio, Marshall, Martin, Martinez-Agosto, Maruyama, Massard, Masuda, Mayr, McCormack, McGinnis, Meng, Mericskay, Meuleman, Miller, Miller, Missmer, Missmer, Mueller, Murphy, Nabeshima, Nonchev, Nusse, Onofrio Triolo, Orvis, Owusu-Ansah, Parazzini, Park, Petta, Pinkert, Pizzo, Pizzo, Pizzo, Pérez-Utrilla Pérez, Redwine, Redwine, Reya, Reya, Roberta Granese, Saadat-Gilani, Salmeri, Salvatore Giovanni Vitale, Sampson, Sampson, Sampson, Schnabel, Schnabel, Schnabel, Schofield, Schwab, Selleri, Sham, Shen, Shen, Shimoda, Signorile, Signorile, Signorile, Signorile, Simsek, Sinder, Soares, Sofo, Spencer, Spencer, Spitzer, Spradling, Stroband, Sturlese, Suginami, Taniguchi, Taylor, Taylor, Thibodeau, Triolo, Tsuji, Tumbar, Uemura, Uğur, Vainio, Valkenburg, Vasso Apostolopoulos, Veeman, Vercellini, Vinatier, Vincenza Sofo, Wang, Wang, Wang, Warot, Wiegratz, Wu, Wu, Yamashita, Ye, Young, Yu   +203 more
core   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Epigenetic Alterations Affecting Transcription Factors and Signaling Pathways in Stromal Cells of Endometriosis. [PDF]

PLoS ONE, 2017
Endometriosis is characterized by growth of endometrial-like tissue outside the uterine cavity. Since its pathogenesis may involve epigenetic changes, we used Illumina 450K Methylation Beadchips to profile CpG methylation in endometriosis stromal cells ...
Iveta Yotova, Emily Hsu, Catherine Do, Aulona Gaba, Matthias Sczabolcs, Sabine Dekan, Lukas Kenner, Rene Wenzl, Benjamin Tycko   +8 more
doaj   +1 more source

Fertility preservation in ovarian tumours [PDF]

, 2018
A considerable number of patients with a cancer diagnosis are of childbearing age and have not satisfied their desire for a family. Despite ovarian cancer (OC) usually occurring in older patients, 3%–14% are diagnosed at a fertile age with the overall 5 ...
Bardhi, E., Di Donato, V., Di Pinto, A., Muzii, L., Panici, P. B., Peccatori, F. A., Petrella, M. C., Sassu, C. M., Tomao, F.   +8 more
core   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Diagnostic evaluation of metastatic rhabdomyosarcoma in effusion specimens [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100330/1/dc22987 ...
Afify, Berkes, Castelino-Prabhu, Cessna, Chivukula, Furlong, Hasteh, Hostein, Kishore, Klijanienko, Kumar, Longatto-Filho, Morgenstern, Nelson, Theunissen, Thiryayi   +15 more
core   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue [PDF]

, 2019
学位記番号 ...
Yoshida, Yuka, ヨシダ, ユカ, 吉田, 由佳   +2 more
core