Results 41 to 50 of about 56,095 (256)

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source

Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2

Reproductive Biology and Endocrinology, 2023
Background Early embryo implantation is a complex phenomenon characterized by the presence of an implantation-competent blastocyst and a receptive endometrium.
Aurélie Hennes, Johanna Devroe, Katrien De Clercq, Martina Ciprietti, Katharina Held, Katrien Luyten, Nele Van Ranst, Nina Maenhoudt, Karen Peeraer, Hugo Vankelecom, Thomas Voets, Joris Vriens   +11 more
doaj   +1 more source

From Metabolic Crisis to Molecular Classification: Multidisciplinary Management of Synchronous Endometrioid Ovarian and Endometrial Carcinomas With Massive Tumor Burden

Cancer Nexus, EarlyView.
Managing massive tumor burden in synchronous endometrioid carcinomas. The graphical abstract summarizes the clinical pathway from presentation with massive ascites, pleural effusion, and critical metabolic abnormalities to multidisciplinary stabilization, surgical management, integrated morphologic–molecular classification, and shared decision‐making ...
Anna Homeniuk, Leena Abdalla, Sharon Fitzgerald   +2 more
wiley   +1 more source

Spontaneous hemoperitoneum in a 29‐week pregnancy with a history of endometriosis: A case report and review of the literature

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 31-37, April 2025.
Abstract Spontaneous hemoperitoneum in pregnancy (SHIP) is defined as sudden, nontraumatic intraperitoneal bleeding that occurs during pregnancy or up to 42 days postpartum. The incidence ranges between 4 and 4.9 per 100 000 births. Although seen rarely, it is associated with perinatal morbidity and mortality due to maternal hemodynamic instability ...
Shamsi Mehdiyev, Fatma Basak Tanoglu, Esma Demir Altuncu, Engin Oral   +3 more
wiley   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Genetics of Endometriosis [PDF]

Women's Health, 2015
Endometriosis is a heritable complex disorder that is influenced by multiple genetic and environmental factors. Identification of these genetic factors will aid a better understanding of the underlying biology of the disease. In this article, we describe different methods of studying genetic variation of endometriosis, summarize results from genetic ...
Rahmioglu, Nilufer, Montgomery, Grant W., Zondervan, Krina T.   +2 more
openaire   +5 more sources

Intraoperative color Doppler during manual vacuum aspiration prevents retained products of conception

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate whether intraoperative confirmation of the disappearance of uterine cavity blood flow using color Doppler during manual vacuum aspiration (MVA) for missed miscarriage reduces the occurrence of retained products of conception (RPOC). Methods We conducted a retrospective cohort study of 202 patients who underwent MVA for
Tatsuya Yoshihara, Keito Nakayama, Dai Miyashita, Satoko Sasatsu, Maki Ogi, Yosuke Ono, Osamu Yoshino   +6 more
wiley   +1 more source

Human Endometriotic Lesion‐Derived Small Extracellular Vesicles Impair Macrophage Function in the Peritoneal Microenvironment

Journal of Extracellular Vesicles
Endometriosis (EM) is a chronic inflammatory disease that affects ∼10% of women during reproductive age. It is characterised by ectopic (ECT) growth of endometrial‐like tissue mainly in the pelvic cavity.
Yifan Wang, Zhixing Jin, Abigail Freeman Blatchford, Banayot Hosh, Malak Amer, Ayazhan Akhatova, Krina Zondervan, Erin Greaves, Rebecca Dragovic, Christian M Becker, Jen Southcombe   +10 more
doaj   +1 more source

Prescription trends for combined oral contraceptives and thromboembolism incidence in Japan before and after public awareness events in 2013–2015

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Combined oral contraceptives (COCs) for dysmenorrhea management have been covered by the Japanese universal health insurance system since 2008. Several public awareness events regarding COC prescriptions for dysmenorrhea were implemented between 2013 and 2015, including media reports on COC‐related fatalities in 2013, drug safety ...
Risa Ishida, Yusuke Sasabuchi, Kaori Koga, Shiori Itoi, Gentaro Izumi, Daisuke Shigemi, Hiroki Matsui, Yutaka Osuga, Hideo Yasunaga   +8 more
wiley   +1 more source

Optimizing outcomes in intrauterine insemination: A narrative synthesis of two decades of clinical research (2000–2024)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Intrauterine insemination (IUI) is a widely used first‐line fertility treatment, yet its success rates vary considerably. This review synthesizes evidence from peer‐reviewed studies published between 2000 and 2024, including randomized controlled trials, cohort and case–control studies, as well as systematic and narrative reviews identified ...
Kasuni Akalanka
wiley   +1 more source