Results 71 to 80 of about 212,283 (373)

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

CGRP neuropeptide levels in patients with endometriosis-related pain treated with dienogest: a comparative study

BMC Women's Health
Background and objective Endometriosis (EM) involves the peripheral nervous system and causes chronic pain. Sensory nerves innervating endometriotic lesions contribute to chronic pain and influence the growth phenotype by releasing neurotrophic factors ...
Shahla Chaichian, Ziba Dehghan Firoozabadi, Samaneh Rokhgireh, Kobra Tahermanesh, Abolfazl Mehdizadeh Kashi, Azam Govahi, Sara Minaeian, Mehdi Mehdizadeh, Marziyeh Ajdary   +8 more
doaj   +1 more source

The Burden of Endometriosis on Women’s Lifespan: A Narrative Overview on Quality of Life and Psychosocial Wellbeing

International Journal of Environmental Research and Public Health, 2020
Endometriosis is a chronic, inflammatory disease affecting more than 170 million women worldwide and up to 10% of women of reproductive age. As a consequence of inflammatory reaction and infiltration of anatomic structures, endometriosis can cause “pain ...
L. Della Corte, C. Di Filippo, Olimpia Gabrielli, Sabrina Reppuccia, V. L. La Rosa, R. Ragusa, M. Fichera, Elena Commodari, G. Bifulco, P. Giampaolino   +9 more
semanticscholar   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

ENDOMETRIOSIS

Clinical Obstetrics and Gynecology, 1952
Significant endometriosis was found in 17.1 per cent of 1,565 patients who had abdominal gynecologic operations. Seventy-seven patients had resection of endometriosis with preservation of reproductive function; 70 were married; and 42 (60 per cent) conceived. Twenty-two of these couples had other infertility problems or were using contraception.
openaire   +5 more sources

Endometriosis in Adolescence [PDF]

Obstetrics and Gynecology International, 2012
Endometriosis is a common cause of pelvic pain and infertility. The majority of women report symptoms since adolescence, and there are rare cases of endometriosis in premenarchal age patients. Symptoms in adolescence are similar to those in adulthood. Treatment usually consists of oral contraceptives and nonsteroidal anti-inflammatory drugs.
Dessole M, MELIS, GIAN BENEDETTO, ANGIONI, STEFANO   +2 more
openaire   +4 more sources

A Wearable In‐Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood

Advanced Science, EarlyView.
MenstruAI integrates a paper‐based biosensor into sanitary pads to detect biomarkers in menstrual blood, enabling accessible, lab‐free diagnostics health. The platform supports early disease detection, especially in underserved communities, while challenging menstrual stigma and opening pathways for scalable, inclusive, and sustainable population ...
Lucas Dosnon, Thomas Rduch, Charlotte Meyer, Inge K. Herrmann   +3 more
wiley   +1 more source

Sleep disorders in patients with endometriosis; a cross-sectional study

BMC Women's Health
Background Endometriosis affects 10–15% of women of reproductive age and is considered a critical gynecological problem. Endometriosis causes pain and infertility, both of which can impair the patient’s quality of life.
Shahla Chaichian, Abolfazl Mehdizadehkashi, Ameneh Haghgoo, Marziyeh Ajdary, Roya Derakhshan, Samaneh Rokhgireh, Saeedeh Sarhadi, Banafsheh Nikfar   +7 more
doaj   +1 more source

Effects of Testicular Platelet-Rich Plasma (PRP) Injection on Sperm Parameters in Men with Severe Oligoasthenoteratozoospermia (OAT): A Clinical Evaluation [PDF]

International Journal of Fertility and Sterility
Background: Severe oligoasthenoteratozoospermia (OAT), characterized by a reduced sperm count, motility, andaltered morphology, presents a significant challenge in the field of male infertility.
Faezeh Fazli, Hossein Torkashvand, Ali Reza Soltanian, Ali Babalhavaeji, Hanieh Olomi, Shamim Pilehvari   +5 more
doaj   +1 more source

The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights

International Journal of Molecular Sciences, 2019
The etiopathogenesis of endometriosis is a multifactorial process resulting in a heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still far from being fully elucidated, the current review aims to offer a comprehensive ...
A. Laganà, S. Garzon, M. Götte, P. Viganò, M. Franchi, F. Ghezzi, D. Martin   +6 more
semanticscholar   +1 more source