Results 131 to 140 of about 271,229 (377)
IUCrJ, 2018 The Arenaviridae family, together with the Bunyaviridae and Orthomyxoviridae families, is one of the three negative-stranded RNA viral families that encode an endonuclease in their genome.
Magali Saez-Ayala +5 more
doaj +1 more source
Polymerase-endonuclease amplification reaction for large-scale enzymatic production of antisense oligonucleotide [PDF]
, 2009 Synthetic oligonucleotides are contaminated with highly homologous failure sequences. Oligonucleotide synthesis is difficult to scale up because it requires expensive equipments, hazardous chemicals, and tedious purification process.
Deming Gou, Xiaolong Wang
core +1 more source
Blood, 2011 Activation of the adaptive Ire1-XBP1 pathway has been identified in many solid tumors and hematologic malignancies, including multiple myeloma (MM). Here, we report the identification of STF-083010, a novel small-molecule inhibitor of Ire1.
I. Papandreou +10 more
semanticscholar +1 more source
Human endonuclease V is a ribonuclease specific for inosine-containing RNA
Nature Communications, 2013 Deamination of DNA bases can create missense mutations predisposing humans to cancer and also interfere with other basic molecular genetic processes; this deamination generates deoxyinosine from deoxyadenosine.
Y. Morita +5 more
semanticscholar +1 more source
Induction of kidney endonucleases by DNase I: evidence of endonuclease network
The FASEB Journal, 2012 Endonuclease‐mediated DNA fragmentation is both an immediate cause and a result of apoptosis and all other types of irreversible cell death during kidney injury. It is produced by nine enzymes: DNase I and 2 families, CAD and EndoG, which act simultaneously. However, regulatory links between these enzymes have not been established. We hypothesized that
Anna G. Stewart +7 more
openaire +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Actinobacillus succinogenes is a ruminal microorganism of biotechnological importance due to its capacity to produce succinic acid at high yields. Despite the scientific interest in this organism, molecular vehicles for the transfer and expression of genetic material are limited compared to the existing demand.
Angélica Vallejo‐Giraldo +7 more
wiley +1 more source
ACS Chemical Biology, 2013 Seasonal and pandemic influenza viruses continue to be a leading global health concern. Emerging resistance to the current drugs and the variable efficacy of vaccines underscore the need for developing new flu drugs that will be broadly effective against
J. Bauman +9 more
semanticscholar +1 more source
Approaches to repurposing reverse transcriptase antivirals in cancer
British Journal of Clinical Pharmacology, EarlyView.This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head +2 more
wiley +1 more source
Journal of Biological Chemistry, 2013 Background: DNA apurinic/apyrimidinic (AP) sites are toxic and mutagenic if unrepaired by AP endonucleases. Results: Structural, mutational, and computational analyses of prototypic AP endonucleases APE1 and Nfo identify surprising similarities ...
S. Tsutakawa +15 more
semanticscholar +1 more source
Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer
BioEssays, EarlyView.Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley +1 more source