Plant, Cell &Environment, EarlyView.ABSTRACT Surface immune receptors such as flagellin‐sensitive 2 (FLS2) are critical for plant defence, and their accumulation at the plasma membrane is tightly controlled by the endomembrane system. Here, we identify the Arabidopsis thaliana prenylated Rab acceptor PRA1.F3 as a positive regulator required for efficient accumulation of FLS2 at the ...
Sung Hee Jo +4 more
wiley +1 more source
Activation of IRE1 Endonuclease Activity Regulates Zika Virus Replication and Antiviral Response During Infection in Human Microglia. [PDF]
VirusesHernández-Díaz T +8 more
europepmc +1 more source
Experimental Physiology, EarlyView.ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu +8 more
wiley +1 more source
Advances in large DNA fragment assembly for microbial cell factory engineering
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang +5 more
wiley +1 more source
A new Caenorhabditis elegans apurinic/apyrimidinic (AP) endonuclease engaged in rescue from replication stress-induced arrest. [PDF]
Genet Mol BiolChoi S, Pham HT, Ahn B.
europepmc +1 more source
Technologies for engineering repetitive DNA
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Disruption of protein-protein interaction hotspots in the C-terminal domain of MLH1 confers mismatch repair deficiency. [PDF]
NAR CancerFishwick KM +13 more
europepmc +1 more source
Developmental Neurobiology, Volume 86, Issue 3, July 2026.ABSTRACT Rett syndrome is a neurodevelopmental disorder caused by an X‐linked mutation of the MeCP2 gene. Individuals with Rett syndrome, as well as rodent models of this disorder, demonstrate abnormal cortical responses to sound, which impair auditory discrimination ability.
Isabella K. Myers +6 more
wiley +1 more source
Comparative analysis of Borrelia's Defence mechanisms and their impact on genetic manipulation of low-passage isolates of <i>Borrelia afzelii</i> and <i>Borrelia garinii</i>. [PDF]
Curr Res Microb SciRuivo M +4 more
europepmc +1 more source
Efficient Transgene‐Free Multiplexed Germline Editing via Viral Delivery of an Engineered TnpB
Plant Biotechnology Journal, EarlyView.
Trevor Weiss +14 more
wiley +1 more source