Results 11 to 20 of about 299,455 (330)

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

Nature Communications, 2021
Endonuclease G (ENDOG), a mitochondrial nuclease, is known to participate in many cellular processes, including apoptosis and paternal mitochondrial elimination, while its role in autophagy remains unclear.
Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, A. Basnakian, Hong-Wen Tang, N. Perrimon, Qinghua Zhou   +10 more
semanticscholar   +1 more source

Remdesivir—Bringing Hope for COVID-19 Treatment

Scientia Pharmaceutica, 2020
At the beginning of 2020, the world was swept with a wave of a new coronavirus disease, named COVID-19 by the World Health Organization (WHO 2). The causative agent of this infection is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...
Naser F. Al-Tannak, Ladislav Novotny, Adel Alhunayan   +2 more
doaj   +1 more source

A Structural Perspective of Reps from CRESS-DNA Viruses and Their Bacterial Plasmid Homologues

Viruses, 2021
Rolling circle replication (RCR) is ubiquitously used by cellular and viral systems for genome and plasmid replication. While the molecular mechanism of RCR has been described, the structural mechanism is desperately lacking.
Elvira Tarasova, Reza Khayat
doaj   +1 more source

Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase

Frontiers in Microbiology, 2020
Influenza virus RNA-dependent RNA polymerase (vRdRp) does not have capping activity and relies on the capped RNAs produced by the host RNA polymerase II (RNAPII).
Ao Hu, Ao Hu, Jing Li, Wei Tang, Ge Liu, Ge Liu, Haiwei Zhang, Chunlan Liu, Xulin Chen, Xulin Chen, Xulin Chen   +10 more
doaj   +1 more source

Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea

Frontiers in Microbiology, 2021
Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin, Likui Zhang, Likui Zhang, Mai Wu, Donghao Jiang, Zheng Li, Zhihui Yang   +6 more
doaj   +1 more source

A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

eLife, 2020
EDC4 is a core component of processing (P)-bodies that binds the DCP2 decapping enzyme and stimulates mRNA decay. EDC4 also interacts with mammalian MARF1, a recently identified endoribonuclease that promotes oogenesis and contains a number of RNA ...
William R Brothers, Steven Hebert, Claudia L Kleinman, Marc R Fabian   +3 more
doaj   +1 more source

Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases

Pharmaceutics, 2021
The adult Göttingen Minipig is an acknowledged model for safety assessment of antisense oligonucleotide (ASO) drugs developed for adult indications.
Allan Valenzuela, Claire Tardiveau, Miriam Ayuso, Laura Buyssens, Chloe Bars, Chris Van Ginneken, Pierluigi Fant, Isabelle Leconte, Annamaria Braendli-Baiocco, Neil Parrott, Georg Schmitt, Yann Tessier, Paul Barrow, Steven Van Cruchten   +13 more
doaj   +1 more source

Endonucleolytic processing plays a critical role in the maturation of ribosomal RNA in Methanococcus maripaludis

RNA Biology, 2023
Ribosomal RNA (rRNA) processing and maturation are fundamentally important for ribosome biogenesis, but the mechanisms in archaea, the third form of life, remains largely elusive.
Lei Qi, Huan Liu, Jian Gao, Kai Deng, Xiaoyan Wang, Xiuzhu Dong, Jie Li   +6 more
doaj   +1 more source

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G [PDF]

, 2005
BACKGROUND: In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis
Mishra, Rangnath, Simonson, Michael S
core   +3 more sources

Programmed cell death in Leishmania: biochemical evidence and role in parasite infectivity

Frontiers in Cellular and Infection Microbiology, 2012
Demonstration of features of a programmed cell death (PCD) pathway in protozoan parasites initiated a great deal of interest and debate in the field of molecular parasitology.
Sreenivas eGannavaram, Alain eDebrabant
doaj   +1 more source