Results 11 to 20 of about 271,229 (377)
Annual Review of Biochemistry, 2013 First discovered as a structure-specific endonuclease that evolved to cut at the base of single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component of cellular DNA metabolism.
Lata Balakrishnan, R. Bambara
semanticscholar +4 more sources
The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay
eLife, 2019 Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a series of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide, and targeting of the mRNA for decay (No Go Decay or NGD).
Karole N D'Orazio +5 more
doaj +2 more sources
The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans. [PDF]
PLoS Biology, 2017 Crossing over between homologs is initiated in meiotic prophase by the formation of DNA double-strand breaks that occur throughout the genome. In the major interference-responsive crossover pathway in baker's yeast, these breaks are resected to form 3 ...
Carol M Manhart +5 more
doaj +2 more sources
Endonuclease II, apurinic acid endonuclease, and exonuclease III. [PDF]
Proceedings of the National Academy of Sciences, 1976 An endonuclease of Escherichia coli active on a DNA treated with methylmethane sulfonate has been separated from an endonuclease active on depurinated sites. The former enzyme is disignated here as endonuclease II, while the latter enzyme is designated as apurinic acid endonuclease.
Dollie Kirtikar +2 more
openalex +5 more sources
Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication [PDF]
PLoS Pathogens, 2017 Coronaviruses are of veterinary and medical importance and include highly pathogenic zoonotic viruses, such as SARS-CoV and MERS-CoV. They are known to efficiently evade early innate immune responses, manifesting in almost negligible expression of type-I
Cervantes-Barragan, Luisa, et al.,
core +3 more sources
Fanzor is a eukaryotic programmable RNA-guided endonuclease
Nature, 2023 Fanzor is shown to be an RNA-guided DNA endonuclease, demonstrating that such endonucleases are found in all domains of life and indicating a potential new tool for genome engineering applications.
M. Saito +9 more
semanticscholar +1 more source
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease
Nature, 2021 Transposition has a key role in reshaping genomes of all living organisms1. Insertion sequences of IS200/IS605 and IS607 families2 are among the simplest mobile genetic elements and contain only the genes that are required for their transposition and its
Tautvydas Karvelis +8 more
semanticscholar +1 more source
Biochemistry (Moscow), 2009 Nicking endonucleases are a new type of enzymes. Like restriction endonucleases, they recognize short specific DNA sequence and cleave DNA at a fixed position relatively to the recognition sequence. However, unlike restriction endonucleases, nicking endonucleases cleave only one predetermined DNA strand.
Galina S. Kachalova +5 more
openaire +3 more sources
Nature Communications, 2021 Endonuclease G (ENDOG), a mitochondrial nuclease, is known to participate in many cellular processes, including apoptosis and paternal mitochondrial elimination, while its role in autophagy remains unclear.
Wenjun Wang +10 more
semanticscholar +1 more source
Endonuclease activity in lipocalins [PDF]
Biochemical Journal, 2000 Several lipocalins contain conserved amino acid sequences similar to the phosphodiester bond cleavage domain of sugar non-specific magnesium-dependent nucleases of the Serratia marcescens type. His-89 and Glu-127 of the S. marcescens endonuclease are believed to have a role in the active catalytic site by the attack of a water molecule at the ...
Ben J. Glasgow +3 more
openaire +3 more sources