Results 91 to 100 of about 64,056 (293)
Online High-throughput Mutagenesis Designer Using Scoring Matrix of Sequence-specific Endonucleases
Journal of Integrative Bioinformatics, 2015 CRISPR Cas9 and other sequence-specific endonucleases are fundamental genome editors supporting gene knockout and gene therapy. A speedy and accurate computational allele designer is required for a high through-put gene mutagenesis pipeline using these ...
Guo Dayong +9 more
doaj +2 more sources
Evolutionary Relationships, Design, and Biochemical Characterization of Homing Endonucleases [PDF]
, 2011 Thesis (Ph.D.)--University of Washington, 2011Homing endonucleases, found in all forms of microbial life, facilitate the invasion of host genes often in concert with introns or inteins by generating double stranded breaks in conserved coding sequences ...
Taylor, Gregory, Taylor, Gregory Kevin
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Advanced Science, EarlyView.Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu +23 more
wiley +1 more source
Mobile DNA, 2010 Background The ends of chromosomes, termed telomeres consist of repetitive DNA. The telomeric sequences shorten with cell division and, when telomeres are critically abbreviated, cells stop proliferating.
Yoshitake Kazutoshi +2 more
doaj +1 more source
In vivo cleavage specificity of Trypanosoma brucei editosome endonucleases [PDF]
, 2017 © The Author(s) 2017. RNA editing is an essential post-transcriptional process that creates functional mitochondrial mRNAs in Kinetoplastids. Multiprotein editosomes catalyze pre-mRNA cleavage, uridine (U) insertion or deletion, and ligation as specified
McDermott, S +11 more
core +1 more source
Advanced Science, EarlyView.An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu +10 more
wiley +1 more source
Editorial: The repair of DNA–protein crosslinks
Frontiers in Molecular Biosciences, 2023 Yilun Sun, John L. Nitiss, Yves Pommier
doaj +1 more source
Advanced Science, EarlyView.Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao +25 more
wiley +1 more source
The role of DNA restriction-modification systems in the biology of Bacillus anthracis
Frontiers in Microbiology, 2016 Restriction-modification (R-M) systems are widespread among prokaryotes and, depending on their type, may be viewed as selfish genetic elements that persist as toxin-antitoxin modules or as cellular defense systems against phage infection.
Ramakrishnan eSitaraman
doaj +1 more source
Rapid identification and differentiation of the vaccine strain Rac H from EHV 1 field isolates using a non-radioactive DNA probe [PDF]
, 1992 A method for rapid differentiation between the EHV 1 live vaccine strain Rac H and field isolates is described. Total DNA was isolated from virus-infected small scale cell cultures.
Hübert, P. H. +3 more
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