A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
International Journal of Cancer, Volume 158, Issue 2, Page 291-304, 15 January 2026.Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez +2 more
wiley +1 more source
Bacterial DNA methylases as novel molecular and synthetic biology tools: recent developments. [PDF]
Appl Microbiol BiotechnolFlores-Fernández CN, O'Callaghan CA.
europepmc +1 more source
The Admission of DNA Evidence in State and Federal Courts [PDF]
, 1997 Gordon, Janet A., Smith, George Bundy
core +1 more source
Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
Advanced Functional Materials, Volume 36, Issue 5, 15 January 2026.CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways. [PDF]
Nat CommunFeng J +7 more
europepmc +1 more source
Sacrificial Biofabrication for Vascularization: Concept, Materials, Technologies, and Applications
Advanced Materials, Volume 38, Issue 2, 8 January 2026.Vasculature is indispensable for tissue viability in regenerative medicine. The sacrificial biofabrication enables precise fabrication of vascular channels by using temporary templates that are subsequently removed. This review defines the concept and delves into sacrificial materials, surrounding materials, fabrication technologies, and biomedical ...
Jiezhong Shi +7 more
wiley +1 more source
Fungal Identifier (FId): An Updated Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Approach to Ease Ascomycetous Yeast Isolates' Identification in Ecological Studies. [PDF]
J Fungi (Basel)Abbà S, Valentini B, Stefanini I.
europepmc +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang +8 more
wiley +1 more source
High-efficiency homology-directed insertion into the genome using the engineered homing endonuclease ARCUS. [PDF]
Nucleic Acids ResResly LC +13 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu +20 more
wiley +1 more source