Results 311 to 320 of about 155,310 (382)

Mutagenic Potentials of DNA Interstrand Cross-Links Induced by 7,8-Dihydro-8-Oxoadenine. [PDF]

Molecules
Schmaltz LF, Rodriguez N, Lee S.
europepmc   +1 more source

Structural and Electronic Complexities of a Sulfur‐Bridged Di‐Iron Complex Composed of Mono‐ and Di‐Nitrosyl Units

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Two NO‐containing iron units, biologically relevant as NO storage/release centers, connected by sulfur, display characteristics arising from multiple quantum levels in their extensively delocalized arrangement. Analysis in three charge levels finds the electron distribution almost substantially spread over all atoms of its composition: 2S, 2Fe, and 3NO.
Sarnali Sanfui, Manuel Quiroz, Jialu Li, Yang Ha, Feipeng Yang, Jinghua Guo, Nattamai Bhuvanesh, Brad S. Pierce, Perla B. Balbuena, Paul A. Lindahl, Michael B. Hall, Marcetta Y. Darensbourg   +11 more
wiley   +1 more source

Genome Sequences of Bacteriophages Natasha and RustyBoy, Isolated on <i>Arthrobacter globiformis</i> , and Fazel, Isolated on <i>Gordonia rubripertincta</i> in Southwestern New Mexico. [PDF]

MicroPubl Biol
Merchant R, Kirk V, McClish I, Ferrara M, Garcia L, Oesch R, Barrera-Moncayo I, Blair A, Eaton E, Gatto G, Geoffrion L, Kirkman M, Kouchich-Martens A, Madduri L, Rosa S, Valdez M, Zamora A, DeVeaux L, Jobe N, Goncz K.   +19 more
europepmc   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

Assessing the Functional Significance of Novel and Rare Variants of the <i>SLC26A4</i> Gene Found in Patients with Hearing Loss by Minigene Assay. [PDF]

Int J Mol Sci
Danilchenko VY, Panina EA, Zytzar MV, Orishchenko KE, Posukh OL.   +4 more
europepmc   +1 more source

RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors

Advanced Science, Volume 13, Issue 4, 19 January 2026.
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao, Tianyu Guan, Qianfeng Xia, Chen Chen, Qian Wang, Lan Luo, Hong Lu, Feng Cui   +7 more
wiley   +1 more source

Self-splicing introns in genes of Bastillevirinae bacteriophages. [PDF]

Nucleic Acids Res
Węglewska M, Gracz-Bernaciak J, Bałdysz S, Nowicki G, Barylski J.   +4 more
europepmc   +1 more source

Nucleases: From Primitive Immune Defenders to Modern Biotechnology Tools. [PDF]

Immunology
Hernandez FJ.
europepmc   +1 more source

Engineering of High‐Yield Recombinant Adeno‐Associated Virus Producer Plasmids

Biotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary Recombinant adeno‐associated viruses (AAV) are important in gene therapy but their production may be impaired by non‐optimized gene design. In this study, the authors demonstrate that production was best when the AAV replicase gene was in a wild‐type configuration while the complexity of other genetic elements could ...
Marco T. Radukic, Dinh To Le, Robert Freudenberg, Anne Hammann, Omar Hamdan, Claire Rothschild‐Gronau, Raimund Hoffrogge, Susanne K. Golm, Rebecca C. Feiner, Kathrin E. Teschner, Kristian M. Müller   +10 more
wiley   +1 more source

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source