Results 191 to 200 of about 20,878 (232)
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2020
Since Gottesman introduced the concept of endophenotypes in schizophrenia research, the endophenotype strategy for understanding the genetics of schizophrenia has been used widely. Endophenotypes are wide-ranging laboratory-based quantitative measures from gene transcripts to neurocognition that show deficits in schizophrenia patients and their first ...
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Since Gottesman introduced the concept of endophenotypes in schizophrenia research, the endophenotype strategy for understanding the genetics of schizophrenia has been used widely. Endophenotypes are wide-ranging laboratory-based quantitative measures from gene transcripts to neurocognition that show deficits in schizophrenia patients and their first ...
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Endophenotypes in bipolar disorder†
American Journal of Medical Genetics, 2002AbstractThe search for genes in bipolar disorder has provided numerous genetic loci that have been linked to susceptibility to developing the disorder. However, because of the genetic heterogeneity inherent in bipolar disorder, additional strategies may need to be employed to fully dissect the genetic underpinnings.
Robert H, Lenox +2 more
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Endophenotypes as a measure of suicidality
Journal of Applied Genetics, 2012Suicide is thought to result from the harmful interaction of multiple factors that have social, environmental, neurobiological, and genetic backgrounds. Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disorders, such as affective disorders, schizophrenia, or ...
Dimitry A, Chistiakov +2 more
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2021
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex pathogenesis and very wide clinical phenotypes. To date, a large variety of clinical phenotypes have been grouped into a single diagnosis, and a single therapeutic approach has been used for AD patients with different clinical phenotypes without considering ...
Kwang Hoon Lee, Chang Ook Park
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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex pathogenesis and very wide clinical phenotypes. To date, a large variety of clinical phenotypes have been grouped into a single diagnosis, and a single therapeutic approach has been used for AD patients with different clinical phenotypes without considering ...
Kwang Hoon Lee, Chang Ook Park
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Neurocognitive endophenotypes for bipolar disorder
Bipolar Disorders, 2008Objectives: Neurocognitive deficits have been proposed as vulnerability markers or endophenotypes for the development of bipolar I disorder (BD I). However, few research studies have examined whether neurocognitive deficits also exist in first‐degree relatives of individuals with BD I.Methods: This prospective study examined neurocognitive function ...
Linda V, Frantom +2 more
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[Temperamental endophenotypes].
L'Encephale, 2013Temperament has been defined as the heritable biologically determined core of personality that remains stable throughout the life span and establishes the baseline level of reactivity, mood, and energy of a person. If the link between temperament and mental disorder goes back to the Greco-Roman medicine, Kraepelin was among the first authors to pay ...
J-M, Azorin +10 more
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Schizophrenia endophenotypes as treatment targets
Expert Opinion on Therapeutic Targets, 2007Schizophrenia is a complex disorder that encompasses several clinical symptom domains and functional impairments. Existing treatments are meager, effective only against positive symptoms without benefiting negative symptoms and functional impairments. The drug discovery process has focused mostly on targeting D2 dopamine receptors.
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Discounting of Delayed Rewards as an Endophenotype
Biological Psychiatry, 2015The article by Anokhin et al. (1) in this issue of Biological Psychiatry provides strong evidence of the heritability of the neurobehavioral decision process referred to as the discounting of delayed rewards, or temporal discounting (i.e., the devaluation of a reward as a function of delay to its delivery) (2). Using a standard psychophysical titration
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Emotional endophenotypes in evolutionary psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006Evolutionary psychiatry emerged from the conceptual successes of sociobiology and evolutionary psychology. It will need to avoid the many mistakes that biology-free Evolutionary Psychology has been prey to. It should not ignore the wealth of information that exists between the phenotypic expression of symptoms and the genotypic sources of core brain ...
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