Results 171 to 180 of about 207,246 (261)

Ectopic expression of MUC5B in the respiratory bronchiole initiates endoplasmic reticulum stress in the IPF lung. [PDF]

Am J Respir Cell Mol Biol
Blumhagen RZ, Kurche JS, Cool CD, Heinz D, Ma X, Davidson EJ, Fingerlin TE, Huber JP, Dobrinskikh E, Schwartz DA, Yang IV.   +10 more
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Exercise Exerts Antidepressant Effects via Endoplasmic Reticulum Stress Modulation: Molecular Mechanisms and Research Progress. [PDF]

Biology (Basel)
Zhou XY, Liu YW, Zhong CH, Xu R, Guan K, Li HN, Huang JT, Xue K, Wang Y, Chen XH.   +9 more
europepmc   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Glucocorticoids injure the airway epithelial barrier via endoplasmic reticulum stress-related apoptosis in asthma. [PDF]

Front Pharmacol
You H, Zou W, Wang K, Gan T, Hu J, Tan W, Wang T, Ren L, Geng G, Fu Z, Niu C.   +10 more
europepmc   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Oxidative stress and endoplasmic reticulum stress in acute kidney injury: mechanistic crosstalk and therapeutic modulation. [PDF]

Front Med (Lausanne)
Xu X, Xing Q, Li H, Ding Z, Ren X.
europepmc   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Cardiomyocyte Stim1 Deficiency Exacerbates Doxorubicin Cardiotoxicity by Magnification of Endoplasmic Reticulum Stress [Retraction]. [PDF]

J Inflamm Res
europepmc   +1 more source

Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress. [PDF]

Cell Commun Signal
Rius-Rocabert S, Tur-Planells V, Arranz-Herrero J, Inchausti-Moya I, Miorin L, de Luis EV, Dopazo A, Solera RA, Concepcion AR, Gastaminza P, García-Sastre A, Nistal-Villan E.   +11 more
europepmc   +1 more source