Results 11 to 20 of about 68,602 (293)

The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors

Journal of Neuroinflammation, 2020
Background Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain. The current study aimed to evaluate its antinociceptive effects in bone cancer pain
Evhy Apryani, Usman Ali, Zi-Ying Wang, Hai-Yun Wu, Xiao-Fang Mao, Khalil Ali Ahmad, Xin-Yan Li, Yong-Xiang Wang   +7 more
doaj   +2 more sources

Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10/β-endorphin pathway

Journal of Neuroinflammation, 2019
Background The G protein-coupled receptor 40 (GPR40), broadly expressed in various tissues such as the spinal cord, exerts multiple physiological functions including pain regulation.
Xiao-Fang Mao, Hai-Yun Wu, Xue-Qi Tang, Usman Ali, Hao Liu, Yong-Xiang Wang   +5 more
doaj   +2 more sources

The effects of Beta-Endorphin: state change modification [PDF]

Fluids and Barriers of the CNS, 2015
Beta-endorphin (β-END) is an opioid neuropeptide which has an important role in the development of hypotheses concerning the non-synaptic or paracrine communication of brain messages.
Jan G. Veening, Henk Barendregt
openalex   +2 more sources

Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by Electroacupuncture

Molecular Pain, 2011
BackgroundElectroacupuncture (EA) can produce analgesia by increasing the β-endorphin level and activation of peripheral μ-opioid receptors in inflamed tissues. Endogenous cannabinoids and peripheral cannabinoid CB2 receptors (CB2Rs) are also involved in
Tangfeng Su, Ling-Hong Zhang, Miao Peng, Cai-Hua Wu, Wen Pan, Bo Tian, Jing Shi, Hui‐Lin Pan, Man Li   +8 more
openalex   +2 more sources

ENDORPHIN MASSAGE EFFECT ON BACK PAIN IN THIRD TRIMESTER PREGNANT WOMEN

Indonesian Midwifery and Health Sciences Journal, 2022
Background : Back pain during pregnancy was experienced by many women at certain times during their pregnancy, usually in the third trimester of pregnancy.
Miftahul Munir, Aris Puji Utami, Dwi Kurnia Purnama Sari, Ina Sholikhatin   +3 more
doaj   +1 more source

Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism

International Journal of Molecular Sciences, 2020
β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist of mu opioid receptors, which can be found throughout the body, brain ...
Alexander R Pilozzi, Caitlin Carro, Xudong Huang   +2 more
semanticscholar   +1 more source

β-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling

Scientific Reports, 2023
Solar ultraviolet B (UVB) radiation triggers excessive inflammation, disrupting the epidermal barrier, and can eventually cause skin cancer. A previous study reported that under UVB irradiation, epidermal keratinocytes synthesize the proopiomelanocortin ...
Hyung-Su Kim, Hyoung-June Kim, Yong-Deog Hong, Eui Dong Son, Si-Young Cho   +4 more
doaj   +1 more source

Endogenous Opioid Levels Do Not Correlate With Itch Intensity and Therapeutic Interventions in Hepatic Pruritus

Frontiers in Medicine, 2021
Background: Chronic pruritus affects up to 70% of patients with immune-mediated hepatobiliary disorders. Antagonists of the μ-opioid receptor (MOR) and agonists of the κ-opioid receptor (KOR) are used to treat hepatic itch, albeit with limited success ...
Miriam M. Düll, Katharina Wolf, Marcel Vetter, Peter Dietrich, Peter Dietrich, Markus F. Neurath, Markus F. Neurath, Andreas E. Kremer   +7 more
doaj   +1 more source

Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes

Frontiers in Pharmacology, 2021
Cynandione A, an acetophenone isolated from Cynanchum Wilfordii Radix, exhibits antineuropathic pain effect. This study further explored the target molecule and signaling mechanisms underlying cynandione-A-induced antineuropathic pain.
Qiao-Qiao Han, Min Yin, Zi-Ying Wang, Hao Liu, Jun-Ping Ao, Yong-Xiang Wang   +5 more
doaj   +1 more source

Musical Agency during Physical Exercise Decreases Pain

Frontiers in Psychology, 2018
Objectives: When physical exercise is systematically coupled to music production, exercisers experience improvements in mood, reductions in perceived effort, and enhanced muscular efficiency.
Thomas H. Fritz, Thomas H. Fritz, Thomas H. Fritz, Daniel L. Bowling, Oliver Contier, Joshua Grant, Lydia Schneider, Annette Lederer, Felicia Höer, Eric Busch, Arno Villringer   +10 more
doaj   +1 more source