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Chapter 29 Endorphins and schizophrenia
1992Endorphins are produced in brain neurons, and as neuropeptides, they play a role as neuromessengers in the regulation of endocrine, autonomic, and behavioral functions. This chapter describes three hypotheses concerning a role of endorphins in schizophrenia: the endorphin-excess hypothesis, the γ-type endorphin hypotheses focus, and the fundamental and
Eric Ronken+3 more
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Archives of General Psychiatry, 1980
To study the effects of beta-endorphin in chronic schizophrenia, nine male patients participated in a double-blind crossover comparison of a single intravenous 20-mg injection of beta-endorphin and saline. Bolus injection of beta-endorphin from an albumin-coated syringe produced markedly higher plasma concentrations than did slow intravenous infusion ...
Choh Hao Li+8 more
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To study the effects of beta-endorphin in chronic schizophrenia, nine male patients participated in a double-blind crossover comparison of a single intravenous 20-mg injection of beta-endorphin and saline. Bolus injection of beta-endorphin from an albumin-coated syringe produced markedly higher plasma concentrations than did slow intravenous infusion ...
Choh Hao Li+8 more
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1980
Pain is the behavioural response to external or internal noxious stimuli. Clinical pain is very different from experimental pain and it is proposed that pain forms a hierarchy starting with activation of sensory fibres or internal clues and terminating with processing in the CNS at various levels.
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Pain is the behavioural response to external or internal noxious stimuli. Clinical pain is very different from experimental pain and it is proposed that pain forms a hierarchy starting with activation of sensory fibres or internal clues and terminating with processing in the CNS at various levels.
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1980
Clinical endorphin research in schizophrenia has so far fanned out in the following directions: (a) studies of endorphin concentration in body fluids, and (b) studies of the effects in schizophrenic patients of opiate (endorphin) antagonists, and of endorphins and endorphin derivatives. The main results are reviewed in this paper. The conclusions drawn
W.M.A. Verhoeven, H. M. Van Praag
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Clinical endorphin research in schizophrenia has so far fanned out in the following directions: (a) studies of endorphin concentration in body fluids, and (b) studies of the effects in schizophrenic patients of opiate (endorphin) antagonists, and of endorphins and endorphin derivatives. The main results are reviewed in this paper. The conclusions drawn
W.M.A. Verhoeven, H. M. Van Praag
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1986
Knowledge of the neurochemistry of pruritus is incomplete and as yet there are no drugs available with a specific antipruritic effect. The classical antihistamines are widely used as antipruritic drugs. The rationale for this is mainly based upon the fact that histamine is a potent pruritogen when injected into the skin and that histamine can easily be
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Knowledge of the neurochemistry of pruritus is incomplete and as yet there are no drugs available with a specific antipruritic effect. The classical antihistamines are widely used as antipruritic drugs. The rationale for this is mainly based upon the fact that histamine is a potent pruritogen when injected into the skin and that histamine can easily be
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2016
Sculpting a circus body. Like an Ousmane Sow sculpture. With everything. Like a clay model. Attacking that body with a chisel, like ripping through marble. Engraving a trunk until reaching sap. Relentlessness, effort, daily, permanent, obsessive. Behind the smiles and obvious risks. Behind the wonder of the circus. To shine in the eye of the ring.
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Sculpting a circus body. Like an Ousmane Sow sculpture. With everything. Like a clay model. Attacking that body with a chisel, like ripping through marble. Engraving a trunk until reaching sap. Relentlessness, effort, daily, permanent, obsessive. Behind the smiles and obvious risks. Behind the wonder of the circus. To shine in the eye of the ring.
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1989
Endorphins are peptides found in the brain that bind to opioid receptors. Pro-opiomelanocortin (see page 26) splits to produce enkephalin, α-lipotrophin (αLPH) and endorphins.
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Endorphins are peptides found in the brain that bind to opioid receptors. Pro-opiomelanocortin (see page 26) splits to produce enkephalin, α-lipotrophin (αLPH) and endorphins.
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Endorphins and experimental addiction
Alcohol, 1996Animal studies suggest that the endogenous opioid systems in the brain play an important role in the initiation and maintenance of drug dependence. Opioids in the ventral tegmental area (VTA) may be involved in rewarded behaviors and, consequently, in the initiation of drug self-administration that may be associated with addiction proneness. Opioids in
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