Results 151 to 160 of about 6,169 (296)

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

open access: yesInterdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi   +18 more
wiley   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

open access: yesInterdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang   +7 more
wiley   +1 more source

Longitudinal Changes in the Serum Pepsinogen I/II Ratio With Progression of Gastric Atrophy

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Serum pepsinogen (PG) I/II ratio decreased with progression of gastric mucosal atrophy and showed consistent intra‐individual changes over time. In a large cohort with repeated endoscopic evaluations, longitudinal declines in the PG I/II ratio paralleled worsening atrophic stages.
Soie Chung   +5 more
wiley   +1 more source

Feasibility of Comprehensive Genomic Profiling for Biliary Tract Cancer Using Transpapillary Biopsy Samples: A Prospective Study

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
Graphical summary of the study design, intervention, and outcomes. ABSTRACT Background Patients with biliary tract cancer (BTC) often have actionable mutations, and comprehensive genomic profiling (CGP) plays an important role. However, the feasibility of CGP using transpapillary biopsy (TPB) samples remains unclear.
Kazuya Miyamoto   +9 more
wiley   +1 more source

Clinical Evaluation of the Effectiveness of Digital Peroral Cholangioscopy‐Guided Lithotripsy for Difficult Bile Duct Stones

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background and Aims Peroral cholangioscopy‐guided lithotripsy (POCS‐L) has emerged as a treatment option for difficult bile duct stones (DBDSs), but detailed evidence remains limited. This study evaluated its effectiveness, safety, and risk factors for adverse events (AEs).
Hirohito Minami   +9 more
wiley   +1 more source

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