Results 121 to 130 of about 25,057,042 (262)

Meta‐Analysis: Redefining Liver Disease Risk in Heterozygous Alpha‐1 Antitrypsin Deficiency

Alimentary Pharmacology &Therapeutics, EarlyView.
SERPINA1 MZ/SZ genotypes is a common but under‐recognised liver risk state. Despite modest shifts in liver function tests, it is associated with approximately doubled odds of fibrosis, cirrhosis, and liver transplantation, supporting its inclusion in chronic liver disease risk assessment.
Adam M. Syanda, Dimitra Georgantaki, Riona T. T. Linn, Amara Agbai, Hassan Tahir, Manako Sakai, Richard Thompson, Mariam Molokhia, S. Tamir Rashid   +8 more
wiley   +1 more source

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, EarlyView.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Appropriate use of endoscopy in the diagnosis and treatment of gastrointestinal diseases: up-to-date indications for primary care providers

International Journal of General Medicine, 2010
Vien X Nguyen1, Vi Thuy Le Nguyen2, Cuong C Nguyen11Department of Gastroenterology, Mayo Clinic, Scottsdale, AZ, USA; 2Department of Pharmacy, Banner Baywood Medical Center, Mesa, AZ, USAAbstract: The field of endoscopy has revolutionized the diagnosis ...
Vien X Nguyen, Vi Thuy Le Nguyen, Cuong C Nguyen   +2 more
doaj  

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4

Cancer Science, EarlyView.
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui, Changfeng Li, Yuanda Liu, Chang Liu, Wei Yang   +4 more
wiley   +1 more source

Top 5 Advances in the Last 50 Years: Malignant Gastric and Esophageal Surgery

World Journal of Surgery, EarlyView.
Luís Santos Castro, Lorenzo Ferri
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

What Are Computer‐Assisted Methods Achieving in Fine‐Needle Aspiration Cytology of the Pancreas? A Systematic Review and Meta‐Analysis

Cytopathology, EarlyView.
This meta‐analysis demonstrates high diagnostic accuracy of computer‐assisted methods in pancreatic EUS‐FNA cytology (AUC 0.92–0.96) and supports an integrated, cytopathologist‐led workflow in which artificial intelligence functions as an adjunct to diagnostic interpretation and on‐site evaluation (ROSE). Created in BioRender. Mohamed Mirzan, A. (2026)
Al‐Amaan Mohamed Mirzan, Roberto Dina
wiley   +1 more source

Small Bowel Lesions and Bleeding Risk in Hemodialysis Patients: A Narrative Review

Hemodialysis International, EarlyView.
ABSTRACT Background Gastrointestinal bleeding is very common among hemodialysis patients. This high bleeding risk is caused by uremic platelet dysfunction, vascular fragility, intradialytic hemodynamic instability, and widespread antithrombotic therapy.
Andreas Smyrlis, Konstantia Kantartzi, Konstantinos Mimidis, Stylianos Panagoutsos   +3 more
wiley   +1 more source

Relationships Between Job Engagement and Self‐Efficacy, Perceived Organisational Support and Perceived Job Security for Newly Recruited Nurses: A Cross‐Sectional Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To examine the relationships among perceived organisational support, perceived job security, self‐efficacy and job engagement among newly recruited nurses and the mediating role of perceived job security and self‐efficacy in the relationship between perceived organisational support and job engagement.
Rongfei Suo, Xiao'e Zeng, Liru Hao, Xiuping Ye, Haifeng Huang, Xiujun Fan, Zhen Ning, Yichun Zhang, Lidan Pang, Lihua Zhang, Xiaoha Lin, Song Zhou   +11 more
wiley   +1 more source

Does Local Excision Without Salvage Surgery Affect the Prognostic Outcome of Patients With Malignant Colorectal Polyp? A Long‐Term Survival Analysis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Management of malignant colorectal polyp has been a treatment dilemma for clinicians. This study aims to evaluate the long‐term survival outcome of patients with and without salvage surgery after local excision. Methods From January 2000 to December 2022, patients with T1 malignant colorectal polyp diagnosed after local ...
Vienna Man Wah Ng, Simon Chu, Anson Huen Yan Chan, Sok Fei Hon, Simon Siu Man Ng   +4 more
wiley   +1 more source