Results 161 to 170 of about 550,585 (195)

Influence of Hypoxia on a Biomaterial Model of the Bone Marrow Perivascular Niche

Advanced Healthcare Materials, EarlyView.
Hypoxia is a key factor in bone marrow physiology and hematopoietic stem cell behavior. Lower oxygen tension influences the secretion of vasculature‐derived hematopoietic regulatory factors and alters hematopoietic cell behavior in a conditioned medium hydrogel model of bone marrow. Cyclosporin A is used to mitigate normoxic stress during hematopoietic
Gunnar B. Thompson, Victoria R. Barnhouse, Sydney K. Bierman, Brendan A.C. Harley   +3 more
wiley   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source

A Highly Adaptable Hydrogen Bond Re‐Orientation (HyBRO) Strategy for Multiscale Vasculature Fabrication

Advanced Materials, EarlyView.
A novel hydrogen bond re‐orientation (HyBRO) strategy enables three‐dimensional (3D) printing of vascular microchannel networks with high accuracy. By switching sacrificial material interactions with nonsolvents, HyBRO prevents swelling and deformation, enabling accurate hierarchical channels spanning a tenfold size range.
Zhencheng Liao, Yu Liu, Chonghao Chen, Iek Man Lei, Lei Dong, Chunming Wang   +5 more
wiley   +1 more source

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases

Advanced Materials, EarlyView.
This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu, Rockie Haiyao Ding, Zixuan Zhao, Clara Yieh Lin Chong, Ruochii You, Hengjia Zhou, Dong Hua Seah, Wei Qiang Leow, Hong Kit Lim, Sukanya Shyamasundar, Kanishka Fernando, Fathima Farzana Kuthubudeen, Gillian Ng, Chor Yong Tay, Narayanan Gopalakrishna Iyer, Chin‐Ann Johnny Ong, Eliza Li Shan Fong   +16 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Endothelial Cell Signaling and Endothelial Dysfunction

American Journal of Hypertension, 1995
Endothelial cells have an important protective role in maintaining the normal physiologic function of the vascular wall. When these cells become dysfunctional, they lose this protective influence and they actively promote pathophysiological changes within the blood vessel. This review will discuss some of the extracellular signaling mechanisms employed
Flavahan, NA, Vanhoutte, PM
openaire   +5 more sources

Endothelial cell transitions [PDF]

Science, 2018
Are endothelial-to-mesenchymal transitions in various vascular pathologies a consequence, cause, or defense?
Maria Grazia Lampugnani, Maria Grazia Lampugnani, Elisabetta Dejana, Elisabetta Dejana   +3 more
openaire   +2 more sources

An Endothelial Cell Is Not Simply an Endothelial Cell

Stem Cells and Development
Endothelial cells (ECs) are a multifaceted component of the vascular system with roles in immunity, maintaining tissue-fluid balance, and vascular tone. Dysregulation or dysfunction of ECs can have far-reaching implications, leading pathologies ranging from cardiovascular diseases, like hypertension and atherosclerosis, ischemia, chronic kidney disease,
Shiwani Limbu, Kara E. McCloskey
openaire   +2 more sources

Endothelial cell‐to‐cell junctions

The FASEB Journal, 1995
The endothelium forms the main barrier to the passage of macromolecules and circulating cells from blood to tissues. Endothelial permeability is in large part regulated by intercellular junctions. These are complex structures formed by transmembrane adhesive molecules linked to a network of cytoplasmic/cytoskeletal proteins.
Monica Corada, Elisabetta Dejana, Maria Grazia Lampugnani   +2 more
openaire   +3 more sources