Results 171 to 180 of about 643,976 (288)

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia

, 2007
Francesco Cosentino, David Hürlimann, Chiara Gatti, Rémy Chenevard, Nenad Blau, N. J., Keith M. Channon, Masato Eto, P. Lerch, Frank Enseleit, Frank Ruschitzka, Massimo Volpe, Thomas F. Lüscher, G. Noll   +13 more
openalex   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis. [PDF]

Clin Transl Med
Xie X, Liu T, Zhang C, Cheng Y, Gao Y, Xiao W, Guo H, Zhou Y, Yu Y, Wang K, Lin Y, Xiao L, Zhang Y, Yang W, Yan G, Lu G, Zhou Y.   +16 more
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Single-capillary endothelial dysfunction resolved by optoacoustic mesoscopy. [PDF]

Light Sci Appl
He H, Karlas A, Fasoula NA, Fischer C, Darsow U, Kallmayer M, Aguirre J, Eckstein HH, Ntziachristos V.   +8 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination. [PDF]

PLoS Pathog
Puerta-Guardo H, Biering SB, Castillo-Rojas B, DiBiasio-White MJ, Lo NTN, Espinosa DA, Warnes CM, Wang C, Cao TM, Glasner DR, Beatty PR, Kuhn RJ, Harris E.   +12 more
europepmc   +1 more source

Clinical implications of endothelial dysfunction [PDF]

, 1998
Carl J. Pepine
openalex   +1 more source

Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells

Advanced Science, EarlyView.
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha, Benjamin Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb K. Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen B. Chen, Lu Wei   +13 more
wiley   +1 more source

Endothelial dysfunction markers in cervical cancer and their influence on patient outcome. [PDF]

Mol Biol Rep
Raeck J, da Silva JB, Carvalho L, Salgado L, Pereira D, Neto BV, Tavares V, de Melo IG, Medeiros R.   +8 more
europepmc   +1 more source