Results 81 to 90 of about 797,667 (303)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Boyd, Alasdair R., Stuart A. Ritchie, Ian P. Salt, Salt, Ian P., Kohlhaas, Christine F, Yalla, Krishna C, Kohlhaas, Christine F., Boyd, Alasdair R, Krishna C. Yalla, Walsh, Kenneth, Ritchie, Stuart A, John M. C. Connell, Christine F. Kohlhaas, Kenneth Walsh, Ritchie, Stuart A., Connell, John M.C., Connell, John Mc, Salt, Ian P, Alasdair R. Boyd, Yalla, Krishna C.   +19 more
core   +1 more source

Evaluation of the EndoPAT as a Tool to Assess Endothelial Function

International Journal of Vascular Medicine, 2012
Endothelial dysfunction is a potential target for (pharmaceutical) intervention of several systemic pathological conditions. We investigated the feasibility of the EndoPAT to evaluate acute changes in endothelial function with repeated noninvasive ...
M. Moerland, A. J. Kales, L. Schrier, M. G. J. van Dongen, D. Bradnock, J. Burggraaf   +5 more
doaj   +1 more source

Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women

Cardiology Research and Practice, 2020
Background/Aims. Sexual differences exist in endothelial progenitor cells (EPCs), and various cardiovascular risk factors are associated with the preservation of endothelial function in premenopausal women.
Shaohong Wu, Hao He, Ge-Xiu Liu, Xiao-Peng Li, Shun Yao, Huan-Xing Su, Xiang Li, Zi Ren, Haitao Zeng, Jinli Liao   +9 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine [PDF]

There is evidence to suggest that hormonal migraine is associated with altered cerebrovascular function. We aimed to investigate whether the expression of genes related to endothelial function in venous blood (1) might influence cerebrovascular function,
Smith, Robert A, Robert A. Smith, Lyn R. Griffiths, Kirsten G. Coupland, Coupland, Kirsten G, Dzator, Jemima SA, Smith, Robert A., Griffiths, Lyn R, Howe, Peter R.C., Dzator, Jemima S. A., Howe, Peter R. C., Coupland, Kirsten G., Dzator, Jemima S.A., Jemima S. A. Dzator, Griffiths, Lyn R., Howe, Peter RC, Peter R. C. Howe, https://orcid.org/   +17 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Overview of the Assessment of Endothelial Function in Humans

Frontiers in Medicine, 2020
The endothelium is recognized to play an important role in various physiological functions including vascular tone, permeability, anticoagulation, and angiogenesis.
Po Ying Chia, Po Ying Chia, Po Ying Chia, Andrew Teo, Andrew Teo, Tsin Wen Yeo, Tsin Wen Yeo, Tsin Wen Yeo   +7 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source