Results 41 to 50 of about 1,408,157 (205)

Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support [PDF]

, 2004
Background - The mechanisms underlying the variation in collateral formation between patients, even with similar patterns of coronary artery disease, remain unclear.
Bucknall, CA, Meng, Y G, Redwood, SR, Pearson, JD, Redwood, S R, Edwards, R J, Lambiase, PD, Marber, MS, Edwards, RJ, Anthopoulos, P, Rahman, S, Lambiase, P D, Meng, YG, Pearson, J D, Marber, M S; id_orcid, Bucknall, C A   +15 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase [PDF]

, 2009
Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT1-, H2O2-, and PYK2-
Loot, Annemarieke E., Ingrid Fleming, Annemarieke E. Loot, Fißlthaler, Beate, Fleming, Ingrid, Judith G. Schreiber, Beate Fisslthaler, Schreiber, Judith G.   +7 more
core   +1 more source

INTERNALISATION OF CALCIUM PHOSPHATE AND MAGNESIUM PHOSPHATE BIONS BY ENDOTHELIAL CELLS UTILISING SCANNING ELECTRON MICROSCOPY AND CONFOCAL MICROSCOPY

Атеросклероз, 2019
Aim of the study was to investigate whether endothelial cells internalise magnesium phosphate and calcium phosphate bions. Material and methods. Magnesium phosphate and calcium phosphate bions synthesised through supersaturation of the culture medium ...
D. K. Shishkova, R. A. Mukhamadiyarov, E. A. Velikanova, Yu. A. Kudryavsteva, A. G. Kutikhin   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Rheology of passive and adhesion-activated neutrophils probed by Atomic Force Microscopy [PDF]

, 2006
The rheology of neutrophils in their passive and activated states plays a key role in determining their function in response to inflammatory stimuli. Atomic force microscopy was used to study neutrophil rheology by measuring the complex shear modulus G ...
Farré, Ramon, Roca-Cusachs Soulere, Pere, Farré Ventura, Ramon, Gavara i Casas, Núria, Almendros López, Isaac, Roca-Cusachs, Pere, Navajas, Daniel, Sunyer, Raimon, Navajas Navarro, Daniel, Almendros, Isaac, Gavara, Núria   +10 more
core   +1 more source

Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment

Cells, 2022
Uveal melanoma (UM) is the most common primary intraocular tumor and often spreads to the liver. Intercellular communication though extracellular vesicles (EVs) plays an important role in several oncogenic processes, including metastasis, therapeutic ...
Léo Piquet, Kelly Coutant, Andrew Mitchell, Amel Ben Anes, Enola Bollmann, Nathan Schoonjans, Julie Bérubé, François Bordeleau, Alain Brisson, Solange Landreville   +9 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Estudio comparativo de los resultados anatómicos y funcionales en el manejo quirúrgico de la catarata utilizando dos modalidades diferentes: extracción extracapsular del cristalino y facoemulsificación Comparative study of the anatomical and functional results of two cataract surgical management techniques: extracapsular extraction of the crystalline and phacoemulsification

Revista Cubana de Oftalmología, 2007
El cambio de una técnica quirúrgica a otra mucho más compleja, no deja de constituir un verdadero reto, más cuando esta técnica requiere de un difícil mecanismo de adaptación a nuevos criterios clínicos y tecnológicos, así como una curva de aprendizaje ...
Gilberto Fernández Vásquez, Juan Raúl Hernández Silva, Marcelino Río Torres, Meisy Ramos López, Luis Curbelo Cunill, Belkys Rodríguez Suárez, Eneida de la Caridad Pérez Candelaria   +6 more
doaj