Results 51 to 60 of about 375,393 (288)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]

, 2008
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Becker, Bernhard F., Chappell, Daniel, Conzen, Peter, Jacob, Matthias, Rehm, Markus, Stoeckelhuber, Mechthild, Welsch, Ulrich   +6 more
core   +1 more source

Confocal microscopy in cornea guttata and Fuchs' endothelial dystrophy [PDF]

British Journal of Ophthalmology, 1999
To report the appearances of cornea guttata and Fuchs' endothelial dystrophy from white light confocal microscopy.Seven eyes of four consecutive patients with cornea guttata were prospectively examined. Of the seven eyes, three also had corneal oedema (Fuchs' dystrophy). In vivo white light tandem scanning confocal microscopy was performed in all eyes.
A G, Chiou, S C, Kaufman, R W, Beuerman, T, Ohta, H, Soliman, H E, Kaufman   +5 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

INTERNALISATION OF CALCIUM PHOSPHATE AND MAGNESIUM PHOSPHATE BIONS BY ENDOTHELIAL CELLS UTILISING SCANNING ELECTRON MICROSCOPY AND CONFOCAL MICROSCOPY

Атеросклероз, 2019
Aim of the study was to investigate whether endothelial cells internalise magnesium phosphate and calcium phosphate bions. Material and methods. Magnesium phosphate and calcium phosphate bions synthesised through supersaturation of the culture medium ...
D. K. Shishkova, R. A. Mukhamadiyarov, E. A. Velikanova, Yu. A. Kudryavsteva, A. G. Kutikhin   +4 more
doaj   +1 more source

Quantitative assessment of angiogenesis in murine antigen-induced arthritis by intravital fluorescence microscopy [PDF]

, 2003
Inhibition of angiogenesis might be a therapeutic approach to prevent joint destruction caused by the overgrowing synovial tissue during chronic joint inflammation.
Krombach, F., Landes, J., Messmer, K., Pellengahr, C., Refior, H. J., Schmitt-Sody, M., Veihelmann, A., Zysk, S. P.   +7 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment

Cells, 2022
Uveal melanoma (UM) is the most common primary intraocular tumor and often spreads to the liver. Intercellular communication though extracellular vesicles (EVs) plays an important role in several oncogenic processes, including metastasis, therapeutic ...
Léo Piquet, Kelly Coutant, Andrew Mitchell, Amel Ben Anes, Enola Bollmann, Nathan Schoonjans, Julie Bérubé, François Bordeleau, Alain Brisson, Solange Landreville   +9 more
doaj   +1 more source

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury [PDF]

, 1997
Objective: Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the ...
Becker, Bernhard F., Gerlach, Eckehart, Habazettl, Helmut, Kupatt, Christian, Messmer, Konrad, Weber, Christian, Zahler, Stefan   +6 more
core   +1 more source