Results 61 to 70 of about 375,393 (288)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Estudio comparativo de los resultados anatómicos y funcionales en el manejo quirúrgico de la catarata utilizando dos modalidades diferentes: extracción extracapsular del cristalino y facoemulsificación Comparative study of the anatomical and functional results of two cataract surgical management techniques: extracapsular extraction of the crystalline and phacoemulsification

Revista Cubana de Oftalmología, 2007
El cambio de una técnica quirúrgica a otra mucho más compleja, no deja de constituir un verdadero reto, más cuando esta técnica requiere de un difícil mecanismo de adaptación a nuevos criterios clínicos y tecnológicos, así como una curva de aprendizaje ...
Gilberto Fernández Vásquez, Juan Raúl Hernández Silva, Marcelino Río Torres, Meisy Ramos López, Luis Curbelo Cunill, Belkys Rodríguez Suárez, Eneida de la Caridad Pérez Candelaria   +6 more
doaj  

Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke.

PLoS ONE, 2019
ObjectiveTo determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS).MethodsThirty-six ...
Hoda Gad, Adnan Khan, Naveed Akhtar, Saadat Kamran, Ahmed El-Sotouhy, Soha R Dargham, Ioannis N Petropoulos, Georgios Ponirakis, Ashfaq Shuaib, Leopold J Streletz, Rayaz A Malik   +10 more
doaj   +1 more source

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. [PDF]

, 2016
Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development.
de Kreuk, Bart-Jan, Gingras, Alexandre R, Gingras, Anne-Claude, Ginsberg, Mark H, Knight, James Dr, Liu, Jian J   +5 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Corneal endothelial changes after subscleral trabeculectomy with mitomycin-C

Delta Journal of Ophthalmology, 2019
Background Antimetabolites have been proposed to increase the success rate and reduce fibrosis associated with filtering surgery. However, they have cytotoxic effect on corneal endothelial cells.
Faried M Wagdy, Adel G Zaky, Sara N.A Gohar   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Modificaciones del endotelio corneal en cirugía de catarata simultánea con vitrectomía Changes of the corneal endothelium in cataract surgery combined with vitrectomy

Revista Cubana de Oftalmología, 2012
Objetivo: determinar el comportamiento del endotelio corneal en pacientes sometidos a cirugías simultáneas de vítreo y catarata. Métodos: se realizó un estudio observacional, descriptivo y prospectivo.
Zucell Ana Veitía Rovirosa, Malvys Vidal Castillo, Juan Raúl Hernández Silva, Eneida de la Caridad Pérez Candelaria, Ileana Vila Dopico, Francisco Fumero González   +5 more
doaj  

LYSOSOME-DEPENDENT CELL DEATH DEFINES SPECIFIC ENDOTHELIAL TOXICITY OF CALCIUM PHOSPHATE BIONS

Сибирский научный медицинский журнал, 2019
Aim of the study was to identify the mechanism of specific endothelial toxicity related to calcium phosphate bions (CPB). Material and methods. CPB and magnesium phosphate bions (MPB) were artificially synthesised through supersaturation of culture ...
D. K. Shishkova, E. A. Velikanova, R. A. Mukhamadiyarov, A. E. Yuzhalin, Yu. A. Kudryavtseva, A. N. Popova, D. M. Russakov, A. G. Kutikhin   +7 more
doaj   +1 more source