Results 141 to 150 of about 24,309,158 (381)

Endothelin‐1 induces expression of fetal genes through the interleukin‐6 family of cytokines in cardiac myocytes [PDF]

, 1999
Shuichi Saito, Ryuichi Aikawa, Ichiro Shiojima, Ryozo Nagai, Yoshio Yazaki, Issei Komuro   +5 more
openalex   +1 more source

Single oral administration of dronabinol increases ocular blood flow in patients with glaucoma

Acta Ophthalmologica, EarlyView.
Abstract Purpose Glaucoma is a leading cause of irreversible blindness globally, primarily driven by elevated intraocular pressure (IOP). Still, some patients progress despite significant IOP lowering, potentially due to impaired ocular blood flow. This study aimed to evaluate the effects of dronabinol, a synthetic tetrahydrocannabinol derivative, on ...
Theresa Lindner, Viktoria Pai, Patrick Janku, Nikolaus Hommer, Anton Hommer, Marihan Abensperg‐Traun, Liudmyla Petric, Leopold Schmetterer, Gerhard Garhöfer, Doreen Schmidl   +9 more
wiley   +1 more source

Novel pathways of heart failure with preserved ejection fraction [PDF]

, 2016
INTRODUCTION: Diastolic heart failure (HF) i.e., HF with preserved ejection fraction (HFpEF) accounts for ~50% of all clinical HF presentations; but unlike systolic HF i.e., HF with reduced ejection fraction (HFrEF), there are no evidenced based ...
Li, Shanpeng
core   +2 more sources

The correlation between endothelin-1 levels and spirometry in dialysis patients compared to healthy subjects

Monaldi Archives for Chest Disease, 2015
Background and Aim. Several studies demonstrated a six-fold increase in plasma concentration of endothelin-1 (ET-1) in diaysis patients (hemodialysis and peritoneal dialysis) compared to healthy control subjects.
P. Kovačević, M. Stanetić, Z. Rajkovača, S. Veljković, M. Kojicic, F. Joachim Meyer   +5 more
doaj   +1 more source

Vessel‐associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease

Brain Pathology, EarlyView.
This post‐mortem study revealed an increased density of vessel‐associated microglia (VAM) in the temporal lobe in systemic infection and Alzheimer's disease. VAM density was related to brain cytokine levels and markers of cerebrovascular dysfunction and BBB leakage indicating that activated VAM contributes to neurovascular injury in Alzheimer's disease.
Oliver Milner, Robert A. Fisher, Daniel J. Asby, Stephen Cross, Delphine Boche, J. Scott Miners   +5 more
wiley   +1 more source

Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

Neural Regeneration Research
[INLINE:1] Vascular etiology is the second most prevalent cause of cognitive impairment globally. Endothelin-1, which is produced and secreted by endothelial cells and astrocytes, is implicated in the pathogenesis of stroke.
Jie Li, Wen Jiang, Yuefang Cai, Zhenqiu Ning, Yingying Zhou, Chengyi Wang, Sookja Ki Chung, Yan Huang, Jingbo Sun, Minzhen Deng, Lihua Zhou, Xiao Cheng   +11 more
doaj   +1 more source

Cardiovascular, catecholamine, and endothelin-1 responses to stress in young adults [PDF]

, 2001
Bruce S. Alpert
openalex   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Hemodynamic and inotropic effects of endothelin-1 in vivo [PDF]

, 1994
Endothelin-1 (ET-1) is known to have strong vasoactive properties. Contradictory results have been reported with regard to its inotropic effects. This study examined the dose-dependent (500, 1000, 2500, 5000 and 10,000 ng ET-1/kg vs.
Beyer, M. E., Hoffmeister, H. M., Krämer, Bernhard K., Nerz, S.   +3 more
core  

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source