The role of endothelin-1 in pulmonary arterial hypertension [PDF]
Global Cardiology Science & Practice, 2014 Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
A. Chester, M. Yacoub
semanticscholar +3 more sources
Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation [PDF]
Neuron, 2014 Timothy R. Hammond +6 more
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Decreased Endothelin-1 bioavailability impairs aggressiveness of gallbladder cancer cells. [PDF]
Biol ResVidal-Vidal J +8 more
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Endothelin-1 in Health and Disease
International Journal of Molecular Sciences, 2023 Discovered almost 40 years ago, the potent vasoconstrictor peptide endothelin-1 (ET-1) has a wide range of roles both physiologically and pathologically. In recent years, there has been a focus on the contribution of ET-1 to disease.
Katherine M. R. M. Banecki, K. Dora
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Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension
Pathophysiology, 2021 The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding.
Krasimir Kostov, Alexander Blazhev
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Східноукраїнський медичний журнал, 2021 Endothelial dysfunction is considered one of the main mechanisms for the further development of arterial hypertension (AH) and its complications, and endothelin-1 (ЕТ-1) plays one of the key roles in this process.
Yu. O. Smiianova
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Endocan, ET-1, and ETAR Expression Profiles in Unicystic Ameloblastoma, Multicystic Ameloblastoma, and Ameloblastic Carcinoma [PDF]
Middle East Journal of Cancer, 2019 Background: Odontogenic lesions range from simple cysts to benign tumors and carcinomas. Unicystic ameloblastoma is a monocystic lesion and a less aggressive tumor compared to multicystic ameloblastoma.
Soussan Irani, Zhaleh Mohsenifar
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Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction
European Heart Journal, 2020 Aims Endothelin-1 (ET-1) is a potent vasoconstrictor peptide linked to vascular diseases through a common intronic gene enhancer [(rs9349379-G allele), chromosome 6 (PHACTR1/EDN1)].
T. Ford +23 more
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Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats. [PDF]
PLoS ONE, 2012 The molecular mechanism linking aldosterone and endothelin-1 in the development of diabetic nephropathy has not been completely elucidated. Here, we provide evidence showing that streptozotocin-induced diabetic rats have significantly increased ...
Qiaoling Zhou +10 more
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Analysis of Endothelin-1 Concentrations in Individuals with Periodontitis
Scientific Reports, 2020 Endothelin 1 (ET-1) has been shown to have a key role in homeostasis and function of endothelium and maybe fundamental in the relationship between coronary heart disease (CHD) and periodontitis.
G. Isola +4 more
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