Results 61 to 70 of about 23,747,035 (396)
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Role of endothelin-1 in hypertension [PDF]
Current Hypertension Reports, 2003 Endothelin-1 (ET-1) was first characterized as a potent vasoconstrictor and is overexpressed in the vasculature in different models of hypertension, such as deoxycorticosterone acetate-salt rats, Dahl salt-sensitive rats, and stroke-prone spontaneously hypertensive rats. Moreover, patients with moderate to severe hypertension present increased vascular
Marc Iglarz, Ernesto L. Schiffrin
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source
Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome [PDF]
, 2004 The aim of this study was to evaluate the presence of early vascular damage in young normal-weight women with polycystic ovary syndrome (PCOS).Thirty young normal-weight women with PCOS, who had no additional metabolic or cardiovascular diseases, and 30 ...
B. De Simone +9 more
core +1 more source
Advanced Materials Interfaces, EarlyView.This study investigates the impact of nanostructured surface modification on corrosion resistance, HUVEC functions, and platelet interactions of 316L SS for cardiovascular stents. Nanostructured surfaces enhanced HUVEC proliferation, migration, and angiogenesis‐related gene expression while reducing platelet adhesion and hemolysis.
Yasar Kemal Erdogan +2 more
wiley +1 more source
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source
Melanocyte Mitogens Induce Both Melanocyte Chemokinesis and Chemotaxis [PDF]
, 1995 It is believed that during repigmentation of vitiligo, inactive melanocytes in the outer root sheath of the hair follicle become activated, proliferate, and migrate into the depigmented skin.
Horikawa, Tatsuya +5 more
core +1 more source
Pulmonary Circulation, 2020 Enhanced vasoconstriction is increasingly identified as an important contributor to the development of pulmonary hypertension. Chronic hypoxia results in enhanced Rho kinase mediated Ca 2+ sensitization contributing to pressure-dependent pulmonary ...
Charles E Norton +3 more
doaj +1 more source
The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis
Archivum Immunologiae et Therapiae Experimentalis, 2014 Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB.
A. Kowalczyk +4 more
semanticscholar +1 more source
Inhibition of ENaC by Endothelin-1 [PDF]
, 2015 The amiloride-sensitive epithelial Na(+) channel (ENaC) is a key player in the regulation of Na(+) homeostasis. Its functional activity is under continuous control by a variety of signaling molecules, including bioactive peptides of endothelin family.
Alexander Staruschenko, Andrey Sorokin
openaire +2 more sources