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Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension [PDF]

Frontiers in Immunology, 2022
IntroductionInflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc).
Christoph Tabeling, Christoph Tabeling, Christoph Tabeling, Carla R. González Calera, Jasmin Lienau, Jakob Höppner, Thomas Tschernig, Olivia Kershaw, Birgitt Gutbier, Jan Naujoks, Julia Herbert, Bastian Opitz, Achim D. Gruber, Berthold Hocher, Berthold Hocher, Berthold Hocher, Norbert Suttorp, Norbert Suttorp, Harald Heidecke, Gerd-R. Burmester, Gabriela Riemekasten, Elise Siegert, Elise Siegert, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Martin Witzenrath, Martin Witzenrath, Martin Witzenrath   +30 more
doaj   +4 more sources

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

Clinical, Cosmetic and Investigational Dermatology, 2023
Carolina Nunhez da Silva,1 Hélio Amante Miot,1 Tony Fernando Grassi,2 Luciane Alarcão Dias-Melício,2– 4 Leandro Santos,2,3 Ana Cláudia Cavalcante Espósito1 1Department of Dermatology, São Paulo State University (UNESP) - Medical School of Botucatu ...
da Silva CN, Miot HA, Grassi TF, Dias-Melício LA, Santos L, Espósito ACC   +5 more
doaj   +6 more sources

Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target? [PDF]

BMC Cancer, 2018
Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed.
Suhas Vasaikar, Giorgos Tsipras, Natalia Landázuri, Helena Costa, Vanessa Wilhelmi, Patrick Scicluna, Huanhuan L. Cui, Abdul-Aleem Mohammad, Belghis Davoudi, Mingmei Shang, Sharan Ananthaseshan, Klas Strååt, Giuseppe Stragliotto, Afsar Rahbar, Kum Thong Wong, Jesper Tegner, Koon-Chu Yaiw, Cecilia Söderberg-Naucler   +17 more
doaj   +2 more sources

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor [PDF]

BMC Cancer, 2008
Background Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35, with two ...
Patterson Paul H, Montgomery Jennifer P
doaj   +5 more sources

Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline [PDF]

eLife
Peripheral sensory neurons regenerate their axons after injury to regain function, but this ability declines with age. The mechanisms behind this decline are not fully understood.
Rui Feng, Sarah F Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Oshri Avraham, Cedric G Geoffroy, Valeria Cavalli   +7 more
doaj   +2 more sources

The gastrointestinal endothelin system: receptors, cellular actions, and involvement in gastrointestinal disorders [PDF]

Gastroenterology Review
The gastrointestinal endothelin system regulates vital processes including motility, secretion, sensation, and inflammation. Endothelin-1 acts via endothelin A and B receptors expressed on diverse intestinal cells.
Arjun Singh, Rajvir Singh
doaj   +2 more sources

Endothelin B receptor dysfunction mediates elevated myogenic tone in cerebral arteries from aged male Fischer 344 rats. [PDF]

Geroscience, 2021
Young AP, Zhu J, Bagher AM, Denovan-Wright EM, Howlett SE, Kelly MEM.   +5 more
europepmc   +3 more sources

Generating CAR-macrophages to target endothelin B receptor-positive tumors [PDF]

Cancer Immunology, Immunotherapy
The endothelin axis is highly involved and overexpressed in many tumors, making it an interesting therapeutic target. However, except for strategies based on small molecule antagonists, this axis is poorly targeted by immunotherapy approaches.
Cyril Lherminier, Narciso Costa, Amaury Herbet, Marie Hautière, Aloïse Mabondzo, Jérémie Martinet, Didier Boquet   +6 more
doaj   +2 more sources

Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan [PDF]

Journal of International Medical Research
Background Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective prevention remains challenging.
Zhengjia Wang, Renshu Zhan, Liqun Mo, Yingying Zhang, Yirong Chen, Li Liu, Yiping Bai   +6 more
doaj   +2 more sources

Differences in Endothelin B Receptor Isoforms Expression and Function in Breast Cancer Cells. [PDF]

J Cancer, 2020
Halaka M, Hired ZA, Rutledge GE, Hedgepath CM, Anderson MP, St John H, Do JM, Majmudar PR, Walker C, Alawawdeh A, Stephen HM, Reagor CC, Adereti J, Jamison K, Iglesias KP, Kirmani KZ, Conway RE.   +16 more
europepmc   +3 more sources