Results 131 to 140 of about 84,913 (300)

P-274: Activated endothelin system in polyglobulia [PDF]

, 2017
The role of the endothelin system, the functional counterpart of NO, in the pathophysiology of polyglobulia remains still elusive. Therefore a novel erythropoietin overexpressing mouse was generated, with hematocrit levels of about 80%.
Gassmann, Max, Hermann, Matthias, Hocher, Berthold, Luscher, Thomas F., Quaschning, Thomas, Ruschitzka, Frank   +5 more
core  

Endothelin-B Receptor Activation in Astrocytes Regulates the Rate of Oligodendrocyte Regeneration during Remyelination [PDF]

, 2015
Timothy R. Hammond, Brian McEllin, Paul D. Morton, Matthew Raymond, Jeffrey L. Dupree, Vittorio Gallo   +5 more
openalex   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Methods to Evaluate the Effect of Ethanol on the Folate Analogue: Fluorescein Methotrexate Uptake in Human Proximal Tubular Cells

Advances in Pharmacological Sciences, 2009
Ethanol-induced folate deficiency is due to effects of ethanol on folate metabolism and absorption. We have already shown by using different methods that ethanol interferes with reabsorption of folate from the proximal tubule. In this study, we have used
Sivakumar JT Gowder, Kenneth E. McMartin
doaj   +1 more source

Endothelin (ET)‐1 and ET‐3 promote expression ofc‐fosandc‐junin human choriocarcinoma via ET_Breceptor‐mediated G_i‐ and G_q‐pathways and MAP kinase activation [PDF]

, 2008
Anamaria Rauh, Werner Windischhofer, Alexander Kovacevic, Trevor DeVaney, Eveline Huber, Michaela Semlitsch, H‐J Leis, Wolfgang Sattler, Ernst Malle   +8 more
openalex   +1 more source

Hetero- and homodimerisation of endothelin A and endothelin B receptors

, 2006
Endothelin-1 (ET-1) ist ein potentes vasoaktives Peptid dessen Wirkung über den Endothelin-A- (ETA) und den Endothelin-B-Rezeptor (ETB) vermittelt wird. Obwohl beide Rezeptoren in zahlreichen Zelltypen koexpremiert werden, ist nur wenig darüber bekannt ob diese Heterodimere bilden können.
openaire   +2 more sources

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ET_B receptor [PDF]

, 1996
Volker Breu, Martine Clozel, Kaspar F. Burri, Georges Hirth, Werner Neidhart, Henri Ramuz   +5 more
openalex   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source