Results 251 to 260 of about 84,913 (300)

Endothelin-B receptors activate Gα₁₃

American Journal of Physiology-Cell Physiology, 1999
Endothelin (ET) receptors activate heterotrimeric G proteins that are members of the Gi, Gq, and Gsfamilies but may also activate members of other families such as Gα12/13. Gα13has multiple complex cellular effects that are similar to those of ET. We studied the ability of ET receptors to activate Gα13using an assay for G protein α-chain activation ...
K, Kitamura, N, Shiraishi, W D, Singer, M E, Handlogten, K, Tomita, R T, Miller   +5 more
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Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma

Journal of Clinical Pathology, 2015
Background Endothelin-1 (ET-1) acting through endothelin A and B receptors (ETAR and ETBR) has been implicated in the development of cancer. The endothelin axis has not previously been characterised in human pancreatic adenocarcinoma (PAC).
Cook, N, Brais, R, Qian, W, Hak, C Chan Wah, Corrie, P G   +4 more
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Myeloperoxidase upregulates endothelin receptor type B expression

Journal of Molecular and Cellular Cardiology, 2014
Neutrophil recruitment and activation are principal events in inflammation. Upon activation neutrophils release myeloperoxidase (MPO), a heme enzyme, which binds to and transcytoses endothelial cells. Whereas the significance of the subendothelial deposition of MPO has evolved as a critical prerequisite for the enzyme's suppression of nitric oxide (NO⋅)
Denise, Lau, Katalin, Szöcs, Anna, Klinke, Tanja, Rudolph, Volker, Rudolph, Thomas, Streichert, Stefan, Blankenberg, Stephan, Baldus   +7 more
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Posttranslational Modifications of Endothelin Receptor Type B

Trends in Cardiovascular Medicine, 1998
Endothelin receptor type B (ETb) is one of the two ET receptor subtypes, both of which belong to the G protein-coupled receptor (GPCR) superfamily. The primary amino acid sequence of ETb, published in 1990, predicted potential posttranslational modifications of the receptor protein, and in the last couple of years, we and others presented direct ...
Y, Okamoto, H, Ninomiya, T, Masaki
openaire   +2 more sources

Endothelin and endothelin receptors A and B in the human testis

Anatomy and Embryology, 1999
Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore essential for the maintenance of spermatogenesis. The expression and the localisation of ET (endothelin) and its receptors in testicular tissue, in seminiferous tubules and in human testicular capillaries were studied.
S, Ergün, S, Harneit, H J, Paust, A K, Mukhopadhyay, A F, Holstein   +4 more
openaire   +2 more sources

Endothelin induces dopamine release from rat striatum via endothelin-B receptors

Neuroscience, 1998
The aim of the present study was to determine whether local administration of endothelin induces the release of dopamine in the rat striatum and to characterize and localize endothelin receptors in this brain region. Local injection of endothelin-1 (10 pmol) into the ventral striatum of urethane-anaesthetized rats caused an increase of 8 microM in the ...
K M, Webber, J N, Pennefather, G A, Head, M, van den Buuse   +3 more
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Subtype-Specific Endothelin-A and Endothelin-B Receptor Desensitization Correlates with Differential Receptor Phosphorylation

Journal of Cardiovascular Pharmacology, 1998
In the rat cardiovascular system endothelin-1 (ET-1) elicits prolonged physiologic responses mediated by the ETA receptor, whereas the effects mediated by the ETB receptor are transient. The molecular mechanisms for the subtype-specific responses are not yet clear. However, post-translational modifications such as phosphorylation and palmitoylation may
H, Cramer, W, Müller-Esterl, C, Schroeder   +2 more
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Thermostabilization of the Human Endothelin Type B Receptor

Journal of Molecular Biology, 2016
The peptide hormone endothelin, produced by the vascular endothelium, is involved in several physiological functions, including maintenance of vascular tone and humoral homeostasis. Endothelin transmits signals through the endothelin receptor, a G-protein-coupled receptor.
Akiko, Okuta, Kazutoshi, Tani, Shoko, Nishimura, Yoshinori, Fujiyoshi, Tomoko, Doi   +4 more
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Endothelin B receptor stimulation inhibits suicidal erythrocyte death

The FASEB Journal, 2010
ABSTRACT Endothelins (ETs), potent endothelium‐derived mediators, stimulate formation of nitric oxide, which, in turn, protects against suicidal erythrocyte death or eryptosis, characterized by phosphatidylserine exposure at the erythrocyte surface and triggered by increase in cytosolic Ca 2+
Foeller, Michael, Mahmud, Hasan, Qadri, Syed M., Gu, Shuchen, Braun, Manuel, Bobbala, Diwakar, Hocher, Berthold (Prof.), Lang, Florian   +7 more
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Downregulation of Endothelin B Receptors in Cardiomyopathic Hamsters

Cardiology, 1998
The mechanisms responsible for abnormal fluid retention in congestive heart failure (CHF) are unclear. Studies were conducted to elucidate how endothelin (ET) may contribute to salt and water retention. Cardiomyopathic (CM) hamsters with moderate heart failure were employed for in vivo and in vitro trials.
W H, Wong, B P, Wong, E F, Wong, M H, Huang, N L, Wong   +4 more
openaire   +2 more sources